node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HCH_02051 | HCH_03044 | HCH_02051 | HCH_03044 | NAD(P) transhydrogenase; COG1249. | NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.910 |
HCH_02051 | HCH_06886 | HCH_02051 | HCH_06886 | NAD(P) transhydrogenase; COG1249. | NAD-dependent protein deacetylases, SIR2 family; COG0846. | 0.908 |
HCH_02051 | HCH_06993 | HCH_02051 | HCH_06993 | NAD(P) transhydrogenase; COG1249. | ADP-ribose pyrophosphatase; COG1051. | 0.900 |
HCH_02051 | HCH_06994 | HCH_02051 | HCH_06994 | NAD(P) transhydrogenase; COG1249. | Predicted ATPase/kinase involved in NAD metabolism; COG3172. | 0.900 |
HCH_02051 | cobB | HCH_02051 | HCH_00109 | NAD(P) transhydrogenase; COG1249. | NAD-dependent protein deacetylases, SIR2 family; COG0846; Belongs to the sirtuin family. Class III subfamily. | 0.908 |
HCH_02051 | nadD | HCH_02051 | HCH_05846 | NAD(P) transhydrogenase; COG1249. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.900 |
HCH_02051 | nadE | HCH_02051 | HCH_05923 | NAD(P) transhydrogenase; COG1249. | NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.917 |
HCH_02051 | nadK | HCH_02051 | HCH_04592 | NAD(P) transhydrogenase; COG1249. | Predicted sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.906 |
HCH_02051 | pntA | HCH_02051 | HCH_03045 | NAD(P) transhydrogenase; COG1249. | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.909 |
HCH_02051 | sthA | HCH_02051 | HCH_02695 | NAD(P) transhydrogenase; COG1249. | Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.911 |
HCH_03044 | HCH_02051 | HCH_03044 | HCH_02051 | NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | NAD(P) transhydrogenase; COG1249. | 0.910 |
HCH_03044 | HCH_06886 | HCH_03044 | HCH_06886 | NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | NAD-dependent protein deacetylases, SIR2 family; COG0846. | 0.900 |
HCH_03044 | HCH_06993 | HCH_03044 | HCH_06993 | NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | ADP-ribose pyrophosphatase; COG1051. | 0.901 |
HCH_03044 | HCH_06994 | HCH_03044 | HCH_06994 | NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | Predicted ATPase/kinase involved in NAD metabolism; COG3172. | 0.900 |
HCH_03044 | cobB | HCH_03044 | HCH_00109 | NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | NAD-dependent protein deacetylases, SIR2 family; COG0846; Belongs to the sirtuin family. Class III subfamily. | 0.900 |
HCH_03044 | nadD | HCH_03044 | HCH_05846 | NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.905 |
HCH_03044 | nadE | HCH_03044 | HCH_05923 | NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.933 |
HCH_03044 | nadK | HCH_03044 | HCH_04592 | NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | Predicted sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.906 |
HCH_03044 | pntA | HCH_03044 | HCH_03045 | NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.999 |
HCH_03044 | sthA | HCH_03044 | HCH_02695 | NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.910 |