STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Amuc_0959Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (214 aa)    
Predicted Functional Partners:
Amuc_0738
TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: glutamine amidotransferase class-I; GMP synthase domain protein; KEGG: tme:Tmel_0718 GMP synthase, large subunit.
 
 
 0.958
rph
Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
 
    0.952
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.936
Amuc_1580
PFAM: nucleoside diphosphate kinase; KEGG: bfs:BF3733 putative nucleoside diphosphate kinase; Belongs to the NDK family.
 
 0.931
Amuc_1954
PFAM: glutamine amidotransferase class-I; KEGG: azo:azo2531 glutamine amidotransferase.
  
 
 0.904
Amuc_1937
PFAM: phosphoribosyltransferase; KEGG: lga:LGAS_0472 hypoxanthine-guanine phosphoribosyltransferase.
   
 
 0.903
Amuc_0922
PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bcl:ABC1445 5'-nucleotidase; Belongs to the 5'-nucleotidase family.
  
 
  0.901
Amuc_0958
KEGG: cth:Cthe_0458 exodeoxyribonuclease III Xth; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase.
  
    0.739
Amuc_1595
PFAM: ExsB family protein; KEGG: cbb:CLD_3386 conserved hypothetical protein TIGR00268.
 
      0.660
Amuc_0099
KEGG: rca:Rcas_2746 phosphodiesterase, MJ0936 family.
  
  
 0.595
Your Current Organism:
Akkermansia muciniphila
NCBI taxonomy Id: 349741
Other names: A. muciniphila ATCC BAA-835, Akkermansia muciniphila ATCC BAA-835, Akkermansia muciniphila Muc, Akkermansia muciniphila str. ATCC BAA-835, Akkermansia muciniphila strain ATCC BAA-835, Akkermansia sp. Muc
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