node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mflv_0342 | Mflv_1254 | Mflv_0342 | Mflv_1254 | PFAM: DNA primase, small subunit; KEGG: mva:Mvan_0396 conserved hypothetical protein. | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | 0.882 |
Mflv_0342 | ku | Mflv_0342 | Mflv_1826 | PFAM: DNA primase, small subunit; KEGG: mva:Mvan_0396 conserved hypothetical protein. | Ku domain protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.894 |
Mflv_0826 | Mflv_1254 | Mflv_0826 | Mflv_1254 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | 0.909 |
Mflv_0826 | Mflv_2255 | Mflv_0826 | Mflv_2255 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: metallophosphoesterase; KEGG: mpa:MAP2494c hypothetical protein. | 0.601 |
Mflv_0826 | Mflv_3097 | Mflv_0826 | Mflv_3097 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: 5'-3' exonuclease; SMART: Helix-hairpin-helix domain protein, class 2; KEGG: mmc:Mmcs_2478 5'-3' exonuclease. | 0.950 |
Mflv_0826 | dinB-3 | Mflv_0826 | Mflv_4310 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.885 |
Mflv_0826 | polA | Mflv_0826 | Mflv_3564 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.997 |
Mflv_1254 | Mflv_0342 | Mflv_1254 | Mflv_0342 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | PFAM: DNA primase, small subunit; KEGG: mva:Mvan_0396 conserved hypothetical protein. | 0.882 |
Mflv_1254 | Mflv_0826 | Mflv_1254 | Mflv_0826 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.909 |
Mflv_1254 | Mflv_1274 | Mflv_1254 | Mflv_1274 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | PFAM: DNA primase, small subunit; KEGG: mva:Mvan_5542 conserved hypothetical protein. | 0.952 |
Mflv_1254 | Mflv_2147 | Mflv_1254 | Mflv_2147 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | PFAM: HhH-GPD family protein; KEGG: mmc:Mmcs_4049 HhH-GPD. | 0.640 |
Mflv_1254 | Mflv_2255 | Mflv_1254 | Mflv_2255 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | PFAM: metallophosphoesterase; KEGG: mpa:MAP2494c hypothetical protein. | 0.631 |
Mflv_1254 | Mflv_3097 | Mflv_1254 | Mflv_3097 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | PFAM: 5'-3' exonuclease; SMART: Helix-hairpin-helix domain protein, class 2; KEGG: mmc:Mmcs_2478 5'-3' exonuclease. | 0.829 |
Mflv_1254 | Mflv_4421 | Mflv_1254 | Mflv_4421 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | PFAM: DNA primase, small subunit; KEGG: mmc:Mmcs_5228 hypothetical protein. | 0.940 |
Mflv_1254 | dinB-3 | Mflv_1254 | Mflv_4310 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.665 |
Mflv_1254 | ku | Mflv_1254 | Mflv_1826 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | Ku domain protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.911 |
Mflv_1254 | polA | Mflv_1254 | Mflv_3564 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.826 |
Mflv_1274 | Mflv_1254 | Mflv_1274 | Mflv_1254 | PFAM: DNA primase, small subunit; KEGG: mva:Mvan_5542 conserved hypothetical protein. | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | 0.952 |
Mflv_1274 | ku | Mflv_1274 | Mflv_1826 | PFAM: DNA primase, small subunit; KEGG: mva:Mvan_5542 conserved hypothetical protein. | Ku domain protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.932 |
Mflv_2147 | Mflv_1254 | Mflv_2147 | Mflv_1254 | PFAM: HhH-GPD family protein; KEGG: mmc:Mmcs_4049 HhH-GPD. | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mva:Mvan_5549 ATP dependent DNA ligase. | 0.640 |