node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mflv_2059 | Mflv_2061 | Mflv_2059 | Mflv_2061 | KEGG: mmc:Mmcs_4132 hypothetical protein. | PFAM: fatty acid desaturase, type 2; KEGG: mmc:Mmcs_4130 fatty acid desaturase, type 2. | 0.486 |
Mflv_2059 | coaA | Mflv_2059 | Mflv_2058 | KEGG: mmc:Mmcs_4132 hypothetical protein. | KEGG: mva:Mvan_4658 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | 0.730 |
Mflv_2059 | glyA | Mflv_2059 | Mflv_2060 | KEGG: mmc:Mmcs_4132 hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.780 |
Mflv_2061 | Mflv_2059 | Mflv_2061 | Mflv_2059 | PFAM: fatty acid desaturase, type 2; KEGG: mmc:Mmcs_4130 fatty acid desaturase, type 2. | KEGG: mmc:Mmcs_4132 hypothetical protein. | 0.486 |
Mflv_2061 | coaA | Mflv_2061 | Mflv_2058 | PFAM: fatty acid desaturase, type 2; KEGG: mmc:Mmcs_4130 fatty acid desaturase, type 2. | KEGG: mva:Mvan_4658 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | 0.454 |
Mflv_2061 | glyA | Mflv_2061 | Mflv_2060 | PFAM: fatty acid desaturase, type 2; KEGG: mmc:Mmcs_4130 fatty acid desaturase, type 2. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.608 |
Mflv_3738 | coaA | Mflv_3738 | Mflv_2058 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | KEGG: mva:Mvan_4658 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | 0.953 |
Mflv_3738 | coaD | Mflv_3738 | Mflv_4196 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.985 |
Mflv_3738 | coaE | Mflv_3738 | Mflv_3559 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.731 |
Mflv_3738 | coaX | Mflv_3738 | Mflv_1426 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.939 |
Mflv_3738 | panC | Mflv_3738 | Mflv_1424 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.894 |
coaA | Mflv_2059 | Mflv_2058 | Mflv_2059 | KEGG: mva:Mvan_4658 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | KEGG: mmc:Mmcs_4132 hypothetical protein. | 0.730 |
coaA | Mflv_2061 | Mflv_2058 | Mflv_2061 | KEGG: mva:Mvan_4658 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | PFAM: fatty acid desaturase, type 2; KEGG: mmc:Mmcs_4130 fatty acid desaturase, type 2. | 0.454 |
coaA | Mflv_3738 | Mflv_2058 | Mflv_3738 | KEGG: mva:Mvan_4658 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.953 |
coaA | coaD | Mflv_2058 | Mflv_4196 | KEGG: mva:Mvan_4658 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.959 |
coaA | coaE | Mflv_2058 | Mflv_3559 | KEGG: mva:Mvan_4658 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.421 |
coaA | coaX | Mflv_2058 | Mflv_1426 | KEGG: mva:Mvan_4658 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.947 |
coaA | glyA | Mflv_2058 | Mflv_2060 | KEGG: mva:Mvan_4658 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.652 |
coaA | panC | Mflv_2058 | Mflv_1424 | KEGG: mva:Mvan_4658 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.930 |
coaD | Mflv_3738 | Mflv_4196 | Mflv_3738 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.985 |