node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mflv_0431 | Mflv_2631 | Mflv_0431 | Mflv_2631 | KEGG: mva:Mvan_0237 bifunctional deaminase-reductase-like protein. | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: mva:Mvan_3950 FolC bifunctional protein. | 0.540 |
Mflv_0431 | thyA | Mflv_0431 | Mflv_4007 | KEGG: mva:Mvan_0237 bifunctional deaminase-reductase-like protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.929 |
Mflv_0431 | thyX | Mflv_0431 | Mflv_4001 | KEGG: mva:Mvan_0237 bifunctional deaminase-reductase-like protein. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.724 |
Mflv_2631 | Mflv_0431 | Mflv_2631 | Mflv_0431 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: mva:Mvan_3950 FolC bifunctional protein. | KEGG: mva:Mvan_0237 bifunctional deaminase-reductase-like protein. | 0.540 |
Mflv_2631 | Mflv_4006 | Mflv_2631 | Mflv_4006 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: mva:Mvan_3950 FolC bifunctional protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.978 |
Mflv_2631 | folD | Mflv_2631 | Mflv_4879 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: mva:Mvan_3950 FolC bifunctional protein. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.459 |
Mflv_2631 | glyA | Mflv_2631 | Mflv_2060 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: mva:Mvan_3950 FolC bifunctional protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.434 |
Mflv_2631 | thyA | Mflv_2631 | Mflv_4007 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: mva:Mvan_3950 FolC bifunctional protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.957 |
Mflv_4006 | Mflv_2631 | Mflv_4006 | Mflv_2631 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: mva:Mvan_3950 FolC bifunctional protein. | 0.978 |
Mflv_4006 | Mflv_5134 | Mflv_4006 | Mflv_5134 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 0.911 |
Mflv_4006 | gcvT | Mflv_4006 | Mflv_2939 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.911 |
Mflv_4006 | glyA | Mflv_4006 | Mflv_2060 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.921 |
Mflv_4006 | thyA | Mflv_4006 | Mflv_4007 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
Mflv_4006 | thyX | Mflv_4006 | Mflv_4001 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.987 |
Mflv_4714 | dut | Mflv_4714 | Mflv_3933 | PFAM: thymidylate kinase; KEGG: mmc:Mmcs_1346 thymidylate kinase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.949 |
Mflv_4714 | thyA | Mflv_4714 | Mflv_4007 | PFAM: thymidylate kinase; KEGG: mmc:Mmcs_1346 thymidylate kinase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.943 |
Mflv_4714 | thyX | Mflv_4714 | Mflv_4001 | PFAM: thymidylate kinase; KEGG: mmc:Mmcs_1346 thymidylate kinase. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.944 |
Mflv_5134 | Mflv_4006 | Mflv_5134 | Mflv_4006 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.911 |
Mflv_5134 | folD | Mflv_5134 | Mflv_4879 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.949 |
Mflv_5134 | gcvT | Mflv_5134 | Mflv_2939 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.922 |