node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mflv_1896 | folD | Mflv_1896 | Mflv_4879 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: mva:Mvan_4834 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.926 |
Mflv_1896 | purN | Mflv_1896 | Mflv_1874 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: mva:Mvan_4834 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.920 |
Mflv_3461 | Mflv_5134 | Mflv_3461 | Mflv_5134 | KEGG: mmc:Mmcs_1546 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 0.920 |
Mflv_3461 | folD | Mflv_3461 | Mflv_4879 | KEGG: mmc:Mmcs_1546 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.926 |
Mflv_3461 | gcvT | Mflv_3461 | Mflv_2939 | KEGG: mmc:Mmcs_1546 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.918 |
Mflv_3461 | glyA | Mflv_3461 | Mflv_2060 | KEGG: mmc:Mmcs_1546 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
Mflv_3461 | thyA | Mflv_3461 | Mflv_4007 | KEGG: mmc:Mmcs_1546 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.914 |
Mflv_5134 | Mflv_3461 | Mflv_5134 | Mflv_3461 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | KEGG: mmc:Mmcs_1546 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.920 |
Mflv_5134 | fmt | Mflv_5134 | Mflv_3730 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.934 |
Mflv_5134 | folD | Mflv_5134 | Mflv_4879 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.949 |
Mflv_5134 | gcvT | Mflv_5134 | Mflv_2939 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.922 |
Mflv_5134 | glyA | Mflv_5134 | Mflv_2060 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.971 |
Mflv_5134 | purH | Mflv_5134 | Mflv_1875 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | KEGG: mva:Mvan_4856 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.950 |
Mflv_5134 | purN | Mflv_5134 | Mflv_1874 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.939 |
Mflv_5134 | purU | Mflv_5134 | Mflv_5090 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.924 |
Mflv_5134 | thyA | Mflv_5134 | Mflv_4007 | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.916 |
fmt | Mflv_5134 | Mflv_3730 | Mflv_5134 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: mva:Mvan_1202 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 0.934 |
fmt | folD | Mflv_3730 | Mflv_4879 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.962 |
fmt | gcvT | Mflv_3730 | Mflv_2939 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.934 |
fmt | glyA | Mflv_3730 | Mflv_2060 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |