node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mvan_1093 | ahcY | Mvan_1093 | Mvan_1746 | KEGG: ngo:NGO0365 site-specific DNA-methyltransferase M.NgoVII; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.912 |
Mvan_1093 | metK | Mvan_1093 | Mvan_2670 | KEGG: ngo:NGO0365 site-specific DNA-methyltransferase M.NgoVII; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.922 |
Mvan_2108 | Mvan_3474 | Mvan_2108 | Mvan_3474 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: mmc:Mmcs_1878 methionine synthase, vitamin-B12 independent. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.923 |
Mvan_2108 | ahcY | Mvan_2108 | Mvan_1746 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: mmc:Mmcs_1878 methionine synthase, vitamin-B12 independent. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.863 |
Mvan_2108 | glyA | Mvan_2108 | Mvan_4656 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: mmc:Mmcs_1878 methionine synthase, vitamin-B12 independent. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.549 |
Mvan_2108 | metK | Mvan_2108 | Mvan_2670 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: mmc:Mmcs_1878 methionine synthase, vitamin-B12 independent. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.903 |
Mvan_2689 | gmk | Mvan_2689 | Mvan_2667 | PFAM: ribulose-phosphate 3-epimerase; KEGG: mmc:Mmcs_2385 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.795 |
Mvan_2689 | guaA | Mvan_2689 | Mvan_1516 | PFAM: ribulose-phosphate 3-epimerase; KEGG: mmc:Mmcs_2385 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.579 |
Mvan_2689 | metK | Mvan_2689 | Mvan_2670 | PFAM: ribulose-phosphate 3-epimerase; KEGG: mmc:Mmcs_2385 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.799 |
Mvan_3474 | Mvan_2108 | Mvan_3474 | Mvan_2108 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: mmc:Mmcs_1878 methionine synthase, vitamin-B12 independent. | 0.923 |
Mvan_3474 | ahcY | Mvan_3474 | Mvan_1746 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.971 |
Mvan_3474 | glyA | Mvan_3474 | Mvan_4656 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.953 |
Mvan_3474 | guaA | Mvan_3474 | Mvan_1516 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.662 |
Mvan_3474 | metK | Mvan_3474 | Mvan_2670 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.971 |
ahcY | Mvan_1093 | Mvan_1746 | Mvan_1093 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | KEGG: ngo:NGO0365 site-specific DNA-methyltransferase M.NgoVII; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase. | 0.912 |
ahcY | Mvan_2108 | Mvan_1746 | Mvan_2108 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: mmc:Mmcs_1878 methionine synthase, vitamin-B12 independent. | 0.863 |
ahcY | Mvan_3474 | Mvan_1746 | Mvan_3474 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.971 |
ahcY | glyA | Mvan_1746 | Mvan_4656 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.583 |
ahcY | guaA | Mvan_1746 | Mvan_1516 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.445 |
ahcY | metK | Mvan_1746 | Mvan_2670 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.862 |