node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mvan_1908 | hisB | Mvan_1908 | Mvan_2806 | KEGG: nfa:nfa44910 putative monophosphatase; TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. | 0.604 |
Mvan_1908 | hisC | Mvan_1908 | Mvan_2805 | KEGG: nfa:nfa44910 putative monophosphatase; TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: mpa:MAP1294 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.925 |
Mvan_1908 | hisD | Mvan_1908 | Mvan_2804 | KEGG: nfa:nfa44910 putative monophosphatase; TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.943 |
Mvan_1908 | hisF | Mvan_1908 | Mvan_2810 | KEGG: nfa:nfa44910 putative monophosphatase; TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.607 |
Mvan_1908 | hisG | Mvan_1908 | Mvan_3470 | KEGG: nfa:nfa44910 putative monophosphatase; TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.601 |
Mvan_1908 | hisH | Mvan_1908 | Mvan_2807 | KEGG: nfa:nfa44910 putative monophosphatase; TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.616 |
Mvan_1908 | hisI | Mvan_1908 | Mvan_2811 | KEGG: nfa:nfa44910 putative monophosphatase; TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.430 |
Mvan_1908 | priA-2 | Mvan_1908 | Mvan_2808 | KEGG: nfa:nfa44910 putative monophosphatase; TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.707 |
Mvan_5596 | hisC | Mvan_5596 | Mvan_2805 | PFAM: Prephenate dehydrogenase; KEGG: mmc:Mmcs_4962 prephenate dehydrogenase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: mpa:MAP1294 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.968 |
Mvan_5596 | pheA | Mvan_5596 | Mvan_5662 | PFAM: Prephenate dehydrogenase; KEGG: mmc:Mmcs_4962 prephenate dehydrogenase. | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: mmc:Mmcs_5034 prephenate dehydratase. | 0.991 |
hisB | Mvan_1908 | Mvan_2806 | Mvan_1908 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. | KEGG: nfa:nfa44910 putative monophosphatase; TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase. | 0.604 |
hisB | hisC | Mvan_2806 | Mvan_2805 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: mpa:MAP1294 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | Mvan_2806 | Mvan_2804 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | Mvan_2806 | Mvan_2810 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | Mvan_2806 | Mvan_3470 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.990 |
hisB | hisH | Mvan_2806 | Mvan_2807 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | Mvan_2806 | Mvan_2811 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.995 |
hisB | pheA | Mvan_2806 | Mvan_5662 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: mmc:Mmcs_5034 prephenate dehydratase. | 0.416 |
hisB | priA-2 | Mvan_2806 | Mvan_2808 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.999 |
hisC | Mvan_1908 | Mvan_2805 | Mvan_1908 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: mpa:MAP1294 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | KEGG: nfa:nfa44910 putative monophosphatase; TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase. | 0.925 |