node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mvan_2729 | Mvan_4056 | Mvan_2729 | Mvan_4056 | TIGRFAM: ABC drug efflux pump, inner membrane subunit, DrrB family; PFAM: ABC-2 type transporter; KEGG: mmc:Mmcs_2432 ABC transporter, DrrB efflux protein. | KEGG: mmc:Mmcs_3603 DsbA oxidoreductase. | 0.435 |
Mvan_2729 | pup | Mvan_2729 | Mvan_3450 | TIGRFAM: ABC drug efflux pump, inner membrane subunit, DrrB family; PFAM: ABC-2 type transporter; KEGG: mmc:Mmcs_2432 ABC transporter, DrrB efflux protein. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.489 |
Mvan_3451 | Mvan_5617 | Mvan_3451 | Mvan_5617 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | KEGG: mmc:Mmcs_4990 hypothetical protein. | 0.692 |
Mvan_3451 | clpS | Mvan_3451 | Mvan_4296 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.557 |
Mvan_3451 | mpa | Mvan_3451 | Mvan_3458 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.884 |
Mvan_3451 | pafA | Mvan_3451 | Mvan_3445 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.416 |
Mvan_3451 | prcA | Mvan_3451 | Mvan_3448 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.959 |
Mvan_3451 | prcB | Mvan_3451 | Mvan_3449 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.952 |
Mvan_3451 | pup | Mvan_3451 | Mvan_3450 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.953 |
Mvan_4056 | Mvan_2729 | Mvan_4056 | Mvan_2729 | KEGG: mmc:Mmcs_3603 DsbA oxidoreductase. | TIGRFAM: ABC drug efflux pump, inner membrane subunit, DrrB family; PFAM: ABC-2 type transporter; KEGG: mmc:Mmcs_2432 ABC transporter, DrrB efflux protein. | 0.435 |
Mvan_4056 | Mvan_5617 | Mvan_4056 | Mvan_5617 | KEGG: mmc:Mmcs_3603 DsbA oxidoreductase. | KEGG: mmc:Mmcs_4990 hypothetical protein. | 0.474 |
Mvan_4056 | clpS | Mvan_4056 | Mvan_4296 | KEGG: mmc:Mmcs_3603 DsbA oxidoreductase. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.414 |
Mvan_4056 | pup | Mvan_4056 | Mvan_3450 | KEGG: mmc:Mmcs_3603 DsbA oxidoreductase. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.445 |
Mvan_5617 | Mvan_3451 | Mvan_5617 | Mvan_3451 | KEGG: mmc:Mmcs_4990 hypothetical protein. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | 0.692 |
Mvan_5617 | Mvan_4056 | Mvan_5617 | Mvan_4056 | KEGG: mmc:Mmcs_4990 hypothetical protein. | KEGG: mmc:Mmcs_3603 DsbA oxidoreductase. | 0.474 |
Mvan_5617 | mpa | Mvan_5617 | Mvan_3458 | KEGG: mmc:Mmcs_4990 hypothetical protein. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.837 |
Mvan_5617 | pafA | Mvan_5617 | Mvan_3445 | KEGG: mmc:Mmcs_4990 hypothetical protein. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.738 |
Mvan_5617 | prcA | Mvan_5617 | Mvan_3448 | KEGG: mmc:Mmcs_4990 hypothetical protein. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.992 |
Mvan_5617 | prcB | Mvan_5617 | Mvan_3449 | KEGG: mmc:Mmcs_4990 hypothetical protein. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.960 |
Mvan_5617 | pup | Mvan_5617 | Mvan_3450 | KEGG: mmc:Mmcs_4990 hypothetical protein. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.679 |