node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mvan_3451 | mpa | Mvan_3451 | Mvan_3458 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.884 |
Mvan_3451 | pafA | Mvan_3451 | Mvan_3445 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.416 |
Mvan_3451 | prcA | Mvan_3451 | Mvan_3448 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.959 |
Mvan_3451 | prcB | Mvan_3451 | Mvan_3449 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.952 |
Mvan_3451 | pup | Mvan_3451 | Mvan_3450 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: mmc:Mmcs_3131 protein of unknown function DUF245-like protein. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.953 |
Mvan_3929 | Mvan_4293 | Mvan_3929 | Mvan_4293 | PFAM: carbohydrate kinase, FGGY; KEGG: mmc:Mmcs_3533 carbohydrate kinase, FGGY; Belongs to the FGGY kinase family. | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: nfa:nfa10890 hypothetical protein. | 0.896 |
Mvan_3929 | Mvan_4494 | Mvan_3929 | Mvan_4494 | PFAM: carbohydrate kinase, FGGY; KEGG: mmc:Mmcs_3533 carbohydrate kinase, FGGY; Belongs to the FGGY kinase family. | PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: mmc:Mmcs_3992 peptidase S1 and S6, chymotrypsin/Hap. | 0.662 |
Mvan_3929 | Mvan_5993 | Mvan_3929 | Mvan_5993 | PFAM: carbohydrate kinase, FGGY; KEGG: mmc:Mmcs_3533 carbohydrate kinase, FGGY; Belongs to the FGGY kinase family. | PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: ade:Adeh_2929 UBA/ThiF-type NAD/FAD binding protein. | 0.902 |
Mvan_3929 | glpK | Mvan_3929 | Mvan_5467 | PFAM: carbohydrate kinase, FGGY; KEGG: mmc:Mmcs_3533 carbohydrate kinase, FGGY; Belongs to the FGGY kinase family. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.917 |
Mvan_3929 | mpa | Mvan_3929 | Mvan_3458 | PFAM: carbohydrate kinase, FGGY; KEGG: mmc:Mmcs_3533 carbohydrate kinase, FGGY; Belongs to the FGGY kinase family. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.932 |
Mvan_3929 | prcA | Mvan_3929 | Mvan_3448 | PFAM: carbohydrate kinase, FGGY; KEGG: mmc:Mmcs_3533 carbohydrate kinase, FGGY; Belongs to the FGGY kinase family. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.862 |
Mvan_3929 | prcB | Mvan_3929 | Mvan_3449 | PFAM: carbohydrate kinase, FGGY; KEGG: mmc:Mmcs_3533 carbohydrate kinase, FGGY; Belongs to the FGGY kinase family. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.862 |
Mvan_4293 | Mvan_3929 | Mvan_4293 | Mvan_3929 | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: nfa:nfa10890 hypothetical protein. | PFAM: carbohydrate kinase, FGGY; KEGG: mmc:Mmcs_3533 carbohydrate kinase, FGGY; Belongs to the FGGY kinase family. | 0.896 |
Mvan_4293 | Mvan_4494 | Mvan_4293 | Mvan_4494 | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: nfa:nfa10890 hypothetical protein. | PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: mmc:Mmcs_3992 peptidase S1 and S6, chymotrypsin/Hap. | 0.633 |
Mvan_4293 | Mvan_5993 | Mvan_4293 | Mvan_5993 | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: nfa:nfa10890 hypothetical protein. | PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: ade:Adeh_2929 UBA/ThiF-type NAD/FAD binding protein. | 0.466 |
Mvan_4293 | glpK | Mvan_4293 | Mvan_5467 | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: nfa:nfa10890 hypothetical protein. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.896 |
Mvan_4293 | mpa | Mvan_4293 | Mvan_3458 | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: nfa:nfa10890 hypothetical protein. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.946 |
Mvan_4293 | prcA | Mvan_4293 | Mvan_3448 | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: nfa:nfa10890 hypothetical protein. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.865 |
Mvan_4293 | prcB | Mvan_4293 | Mvan_3449 | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: nfa:nfa10890 hypothetical protein. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.847 |
Mvan_4494 | Mvan_3929 | Mvan_4494 | Mvan_3929 | PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: mmc:Mmcs_3992 peptidase S1 and S6, chymotrypsin/Hap. | PFAM: carbohydrate kinase, FGGY; KEGG: mmc:Mmcs_3533 carbohydrate kinase, FGGY; Belongs to the FGGY kinase family. | 0.662 |