node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mvan_0637 | Mvan_5541 | Mvan_0637 | Mvan_5541 | PFAM: regulatory protein, MerR; KEGG: mmc:Mmcs_0465 transcriptional regulator, MerR family. | KEGG: cne:CNE03390 hypothetical protein. | 0.871 |
Mvan_0637 | dnaJ | Mvan_0637 | Mvan_0636 | PFAM: regulatory protein, MerR; KEGG: mmc:Mmcs_0465 transcriptional regulator, MerR family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.991 |
Mvan_0637 | dnaJ-2 | Mvan_0637 | Mvan_3836 | PFAM: regulatory protein, MerR; KEGG: mmc:Mmcs_0465 transcriptional regulator, MerR family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.810 |
Mvan_0637 | dnaK | Mvan_0637 | Mvan_0634 | PFAM: regulatory protein, MerR; KEGG: mmc:Mmcs_0465 transcriptional regulator, MerR family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.990 |
Mvan_0637 | groL1 | Mvan_0637 | Mvan_0764 | PFAM: regulatory protein, MerR; KEGG: mmc:Mmcs_0465 transcriptional regulator, MerR family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.489 |
Mvan_0637 | groL2 | Mvan_0637 | Mvan_1495 | PFAM: regulatory protein, MerR; KEGG: mmc:Mmcs_0465 transcriptional regulator, MerR family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.608 |
Mvan_0637 | grpE | Mvan_0637 | Mvan_0635 | PFAM: regulatory protein, MerR; KEGG: mmc:Mmcs_0465 transcriptional regulator, MerR family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.982 |
Mvan_0637 | hrcA | Mvan_0637 | Mvan_3837 | PFAM: regulatory protein, MerR; KEGG: mmc:Mmcs_0465 transcriptional regulator, MerR family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.833 |
Mvan_5541 | Mvan_0637 | Mvan_5541 | Mvan_0637 | KEGG: cne:CNE03390 hypothetical protein. | PFAM: regulatory protein, MerR; KEGG: mmc:Mmcs_0465 transcriptional regulator, MerR family. | 0.871 |
Mvan_5541 | clpP | Mvan_5541 | Mvan_4039 | KEGG: cne:CNE03390 hypothetical protein. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.615 |
Mvan_5541 | dnaJ | Mvan_5541 | Mvan_0636 | KEGG: cne:CNE03390 hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.954 |
Mvan_5541 | dnaJ-2 | Mvan_5541 | Mvan_3836 | KEGG: cne:CNE03390 hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.908 |
Mvan_5541 | groL1 | Mvan_5541 | Mvan_0764 | KEGG: cne:CNE03390 hypothetical protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.865 |
Mvan_5541 | groL2 | Mvan_5541 | Mvan_1495 | KEGG: cne:CNE03390 hypothetical protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.865 |
Mvan_5541 | grpE | Mvan_5541 | Mvan_0635 | KEGG: cne:CNE03390 hypothetical protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.985 |
Mvan_5541 | hrcA | Mvan_5541 | Mvan_3837 | KEGG: cne:CNE03390 hypothetical protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.816 |
argR | clpP | Mvan_3309 | Mvan_4039 | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.454 |
argR | hrcA | Mvan_3309 | Mvan_3837 | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.808 |
clpP | Mvan_5541 | Mvan_4039 | Mvan_5541 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | KEGG: cne:CNE03390 hypothetical protein. | 0.615 |
clpP | argR | Mvan_4039 | Mvan_3309 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. | 0.454 |