STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rskAConserved hypothetical protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degradi [...] (238 aa)    
Predicted Functional Partners:
sigK
RNA polymerase, sigma-24 subunit, ECF subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (By similarity).
 
 
 0.999
Mvan_4926
PFAM: protein of unknown function DUF1365; KEGG: mmc:Mmcs_4370 protein of unknown function DUF1365.
 
     0.865
Mvan_0162
RNA polymerase, sigma subunit, SigZ; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: rba:RB6078 RNA polymerase sigma-70 factor; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.838
Mvan_0876
KEGG: mmc:Mmcs_5162 hypothetical protein.
  
     0.598
Mvan_0874
KEGG: mmc:Mmcs_5160 hypothetical protein.
  
     0.533
Mvan_4925
PFAM: protein of unknown function DUF867; KEGG: mmc:Mmcs_4367 protein of unknown function DUF867.
       0.500
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
      
 0.471
Mvan_3530
KEGG: mmc:Mmcs_3263 FHA domain containing protein.
  
     0.464
Mvan_4461
TIGRFAM: H+ Antiporter protein; PFAM: major facilitator superfamily MFS_1; KEGG: mmc:Mmcs_3958 drug antiporter protein.
  
   
 0.456
Mvan_4924
Hypothetical protein.
       0.442
Your Current Organism:
Mycolicibacterium vanbaalenii
NCBI taxonomy Id: 350058
Other names: M. vanbaalenii PYR-1, Mycobacterium sp. PYR-1, Mycobacterium vanbaalenii DSM 7251, Mycobacterium vanbaalenii PYR-1, Mycolicibacterium vanbaalenii DSM 7251, Mycolicibacterium vanbaalenii PYR-1
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