node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clos_0078 | fhs | Clos_0078 | Clos_2127 | KEGG: cbo:CBO1621 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.693 |
Clos_0078 | folD | Clos_0078 | Clos_0249 | KEGG: cbo:CBO1621 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.966 |
Clos_0078 | gcvT | Clos_0078 | Clos_0065 | KEGG: cbo:CBO1621 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.932 |
Clos_0078 | glyA | Clos_0078 | Clos_1700 | KEGG: cbo:CBO1621 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.949 |
Clos_0294 | Clos_0403 | Clos_0294 | Clos_0403 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | 0.927 |
Clos_0294 | Clos_2263 | Clos_0294 | Clos_2263 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: drm:Dred_2882 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.916 |
Clos_0294 | fhs | Clos_0294 | Clos_2127 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.953 |
Clos_0294 | fmt | Clos_0294 | Clos_1428 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.910 |
Clos_0294 | folD | Clos_0294 | Clos_0249 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.945 |
Clos_0294 | gcvT | Clos_0294 | Clos_0065 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.925 |
Clos_0294 | purH | Clos_0294 | Clos_0541 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.905 |
Clos_0294 | purN | Clos_0294 | Clos_0540 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.907 |
Clos_0403 | Clos_0294 | Clos_0403 | Clos_0294 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | 0.927 |
Clos_0403 | Clos_2263 | Clos_0403 | Clos_2263 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: drm:Dred_2882 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.916 |
Clos_0403 | fhs | Clos_0403 | Clos_2127 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.953 |
Clos_0403 | fmt | Clos_0403 | Clos_1428 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.910 |
Clos_0403 | folD | Clos_0403 | Clos_0249 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.945 |
Clos_0403 | gcvT | Clos_0403 | Clos_0065 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.925 |
Clos_0403 | purH | Clos_0403 | Clos_0541 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.905 |
Clos_0403 | purN | Clos_0403 | Clos_0540 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.907 |