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folD protein (Alkaliphilus oremlandii) - STRING interaction network
"folD" - Bifunctional protein FolD in Alkaliphilus oremlandii
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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folDBifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (285 aa)    
Predicted Functional Partners:
fhs
PFAM- formate-tetrahydrofolate ligase FTHFS; KEGG- dsy-DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family (556 aa)
 
 
  0.997
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (410 aa)
 
 
  0.994
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (368 aa)
   
 
  0.989
purH
Bifunctional purine biosynthesis protein PurH; KEGG- cth-Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM- phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- MGS domain protein; AICARFT/IMPCHase bienzyme formylation region (512 aa)
   
  0.982
Clos_2263
PFAM- 5-formyltetrahydrofolate cyclo-ligase; KEGG- drm-Dred_2882 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family (189 aa)
   
 
  0.966
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (209 aa)
 
 
  0.966
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus (310 aa)
     
  0.961
Clos_0078
KEGG- cbo-CBO1621 5,10-methylenetetrahydrofolate reductase; TIGRFAM- 5,10-methylenetetrahydrofolate reductase; PFAM- methylenetetrahydrofolate reductase (298 aa)
   
 
  0.960
thyX
Flavin-dependent thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant (260 aa)
   
 
  0.914
Clos_2223
KEGG- cno-NT01CX_2418 phosphoribosylformylglycinamidine synthase; TIGRFAM- phosphoribosylformylglycinamidine synthase; PFAM- AIR synthase related protein domain protein (1248 aa)
   
   
  0.908
Your Current Organism:
Alkaliphilus oremlandii
NCBI taxonomy Id: 350688
Other names: A. oremlandii OhILAs, Alkaliphilus oremlandii, Alkaliphilus oremlandii OhILAs, Alkaliphilus oremlandii str. OhILAs, Alkaliphilus oremlandii strain OhILAs, Clostridium oremlandii OhILAs, Clostridium sp. OhILAs
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