node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clos_2338 | Clos_2339 | Clos_2338 | Clos_2339 | PFAM: 2-nitropropane dioxygenase NPD; KEGG: ctc:CTC00125 hypothetical protein. | Threonine aldolase; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: ctc:CTC01037 L-allo-threonine aldolase. | 0.686 |
Clos_2338 | Clos_2340 | Clos_2338 | Clos_2340 | PFAM: 2-nitropropane dioxygenase NPD; KEGG: ctc:CTC00125 hypothetical protein. | PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: drm:Dred_0037 DEAD/DEAH box helicase domain protein. | 0.606 |
Clos_2338 | aroD | Clos_2338 | Clos_2337 | PFAM: 2-nitropropane dioxygenase NPD; KEGG: ctc:CTC00125 hypothetical protein. | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.700 |
Clos_2338 | birA | Clos_2338 | Clos_0444 | PFAM: 2-nitropropane dioxygenase NPD; KEGG: ctc:CTC00125 hypothetical protein. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.461 |
Clos_2339 | Clos_2338 | Clos_2339 | Clos_2338 | Threonine aldolase; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: ctc:CTC01037 L-allo-threonine aldolase. | PFAM: 2-nitropropane dioxygenase NPD; KEGG: ctc:CTC00125 hypothetical protein. | 0.686 |
Clos_2339 | Clos_2340 | Clos_2339 | Clos_2340 | Threonine aldolase; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: ctc:CTC01037 L-allo-threonine aldolase. | PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: drm:Dred_0037 DEAD/DEAH box helicase domain protein. | 0.678 |
Clos_2339 | aroD | Clos_2339 | Clos_2337 | Threonine aldolase; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: ctc:CTC01037 L-allo-threonine aldolase. | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.616 |
Clos_2340 | Clos_2338 | Clos_2340 | Clos_2338 | PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: drm:Dred_0037 DEAD/DEAH box helicase domain protein. | PFAM: 2-nitropropane dioxygenase NPD; KEGG: ctc:CTC00125 hypothetical protein. | 0.606 |
Clos_2340 | Clos_2339 | Clos_2340 | Clos_2339 | PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: drm:Dred_0037 DEAD/DEAH box helicase domain protein. | Threonine aldolase; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: ctc:CTC01037 L-allo-threonine aldolase. | 0.678 |
Clos_2340 | aroD | Clos_2340 | Clos_2337 | PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: drm:Dred_0037 DEAD/DEAH box helicase domain protein. | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.545 |
Clos_2418 | aroD | Clos_2418 | Clos_2337 | PFAM: Shikimate/quinate 5-dehydrogenase; KEGG: tte:TTE2374 hypothetical protein. | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.499 |
Clos_2418 | aroK | Clos_2418 | Clos_1625 | PFAM: Shikimate/quinate 5-dehydrogenase; KEGG: tte:TTE2374 hypothetical protein. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.499 |
Clos_2418 | birA | Clos_2418 | Clos_0444 | PFAM: Shikimate/quinate 5-dehydrogenase; KEGG: tte:TTE2374 hypothetical protein. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.463 |
aroA | aroB | Clos_1359 | Clos_1358 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.999 |
aroA | aroC | Clos_1359 | Clos_1357 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.999 |
aroA | aroD | Clos_1359 | Clos_2337 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.554 |
aroA | aroE | Clos_1359 | Clos_0042 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.996 |
aroA | aroK | Clos_1359 | Clos_1625 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.993 |
aroA | birA | Clos_1359 | Clos_0444 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.515 |
aroB | aroA | Clos_1358 | Clos_1359 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.999 |