node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Maqu_0485 | Maqu_0486 | Maqu_0485 | Maqu_0486 | PFAM: protein of unknown function DUF513, hemX; KEGG: hch:HCH_00289 uncharacterized enzyme of heme biosynthesis. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.994 |
Maqu_0485 | Maqu_1546 | Maqu_0485 | Maqu_1546 | PFAM: protein of unknown function DUF513, hemX; KEGG: hch:HCH_00289 uncharacterized enzyme of heme biosynthesis. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: hch:HCH_02450 uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | 0.904 |
Maqu_0485 | Maqu_3131 | Maqu_0485 | Maqu_3131 | PFAM: protein of unknown function DUF513, hemX; KEGG: hch:HCH_00289 uncharacterized enzyme of heme biosynthesis. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pen:PSEEN2217 siroheme synthase; Belongs to the precorrin methyltransferase family. | 0.904 |
Maqu_0485 | hemC | Maqu_0485 | Maqu_0487 | PFAM: protein of unknown function DUF513, hemX; KEGG: hch:HCH_00289 uncharacterized enzyme of heme biosynthesis. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.857 |
Maqu_0485 | hemE | Maqu_0485 | Maqu_0836 | PFAM: protein of unknown function DUF513, hemX; KEGG: hch:HCH_00289 uncharacterized enzyme of heme biosynthesis. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.907 |
Maqu_0486 | Maqu_0485 | Maqu_0486 | Maqu_0485 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: protein of unknown function DUF513, hemX; KEGG: hch:HCH_00289 uncharacterized enzyme of heme biosynthesis. | 0.994 |
Maqu_0486 | Maqu_1546 | Maqu_0486 | Maqu_1546 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: hch:HCH_02450 uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | 0.941 |
Maqu_0486 | Maqu_3131 | Maqu_0486 | Maqu_3131 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pen:PSEEN2217 siroheme synthase; Belongs to the precorrin methyltransferase family. | 0.939 |
Maqu_0486 | Maqu_3578 | Maqu_0486 | Maqu_3578 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pen:PSEEN5337 delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | 0.901 |
Maqu_0486 | hemC | Maqu_0486 | Maqu_0487 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
Maqu_0486 | hemE | Maqu_0486 | Maqu_0836 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.943 |
Maqu_0486 | hemF | Maqu_0486 | Maqu_0047 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.436 |
Maqu_0486 | hemH | Maqu_0486 | Maqu_1496 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.471 |
Maqu_0834 | Maqu_1546 | Maqu_0834 | Maqu_1546 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: hch:HCH_05965 glutamate synthase domain 2. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: hch:HCH_02450 uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | 0.447 |
Maqu_0834 | Maqu_3100 | Maqu_0834 | Maqu_3100 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: hch:HCH_05965 glutamate synthase domain 2. | KEGG: hch:HCH_02266 oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM domain protein; HemN domain protein; SMART: Elongator protein 3/MiaB/NifB; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.570 |
Maqu_0834 | Maqu_3131 | Maqu_0834 | Maqu_3131 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: hch:HCH_05965 glutamate synthase domain 2. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pen:PSEEN2217 siroheme synthase; Belongs to the precorrin methyltransferase family. | 0.447 |
Maqu_0834 | hemE | Maqu_0834 | Maqu_0836 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: hch:HCH_05965 glutamate synthase domain 2. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.776 |
Maqu_1546 | Maqu_0485 | Maqu_1546 | Maqu_0485 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: hch:HCH_02450 uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | PFAM: protein of unknown function DUF513, hemX; KEGG: hch:HCH_00289 uncharacterized enzyme of heme biosynthesis. | 0.904 |
Maqu_1546 | Maqu_0486 | Maqu_1546 | Maqu_0486 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: hch:HCH_02450 uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.941 |
Maqu_1546 | Maqu_0834 | Maqu_1546 | Maqu_0834 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: hch:HCH_02450 uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: hch:HCH_05965 glutamate synthase domain 2. | 0.447 |