node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Maqu_0357 | Maqu_3751 | Maqu_0357 | Maqu_3751 | NAD pyrophosphatase/5'-nucleotidase NadN; KEGG: hch:HCH_00409 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; TIGRFAM: NAD pyrophosphatase/5'-nucleotidase NadN; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: tbd:Tbd_0839 HAD-superfamily hydrolase subfamily IA, variant 3. | 0.908 |
Maqu_0357 | dut | Maqu_0357 | Maqu_3562 | NAD pyrophosphatase/5'-nucleotidase NadN; KEGG: hch:HCH_00409 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; TIGRFAM: NAD pyrophosphatase/5'-nucleotidase NadN; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
Maqu_0357 | surE | Maqu_0357 | Maqu_0926 | NAD pyrophosphatase/5'-nucleotidase NadN; KEGG: hch:HCH_00409 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; TIGRFAM: NAD pyrophosphatase/5'-nucleotidase NadN; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.915 |
Maqu_0357 | thyA | Maqu_0357 | Maqu_2432 | NAD pyrophosphatase/5'-nucleotidase NadN; KEGG: hch:HCH_00409 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; TIGRFAM: NAD pyrophosphatase/5'-nucleotidase NadN; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.906 |
Maqu_0357 | tmk | Maqu_0357 | Maqu_1862 | NAD pyrophosphatase/5'-nucleotidase NadN; KEGG: hch:HCH_00409 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; TIGRFAM: NAD pyrophosphatase/5'-nucleotidase NadN; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.914 |
Maqu_2431 | dut | Maqu_2431 | Maqu_3562 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.436 |
Maqu_2431 | folD | Maqu_2431 | Maqu_1842 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.401 |
Maqu_2431 | glyA | Maqu_2431 | Maqu_0841 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.942 |
Maqu_2431 | thyA | Maqu_2431 | Maqu_2432 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
Maqu_2431 | tmk | Maqu_2431 | Maqu_1862 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.436 |
Maqu_3044 | folD | Maqu_3044 | Maqu_1842 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: hch:HCH_01531 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.941 |
Maqu_3044 | glyA | Maqu_3044 | Maqu_0841 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: hch:HCH_01531 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
Maqu_3044 | thyA | Maqu_3044 | Maqu_2432 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: hch:HCH_01531 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.934 |
Maqu_3751 | Maqu_0357 | Maqu_3751 | Maqu_0357 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: tbd:Tbd_0839 HAD-superfamily hydrolase subfamily IA, variant 3. | NAD pyrophosphatase/5'-nucleotidase NadN; KEGG: hch:HCH_00409 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; TIGRFAM: NAD pyrophosphatase/5'-nucleotidase NadN; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | 0.908 |
Maqu_3751 | dut | Maqu_3751 | Maqu_3562 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: tbd:Tbd_0839 HAD-superfamily hydrolase subfamily IA, variant 3. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.901 |
Maqu_3751 | surE | Maqu_3751 | Maqu_0926 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: tbd:Tbd_0839 HAD-superfamily hydrolase subfamily IA, variant 3. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.911 |
Maqu_3751 | thyA | Maqu_3751 | Maqu_2432 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: tbd:Tbd_0839 HAD-superfamily hydrolase subfamily IA, variant 3. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.906 |
Maqu_3751 | tmk | Maqu_3751 | Maqu_1862 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: tbd:Tbd_0839 HAD-superfamily hydrolase subfamily IA, variant 3. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.905 |
dut | Maqu_0357 | Maqu_3562 | Maqu_0357 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | NAD pyrophosphatase/5'-nucleotidase NadN; KEGG: hch:HCH_00409 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; TIGRFAM: NAD pyrophosphatase/5'-nucleotidase NadN; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | 0.900 |
dut | Maqu_2431 | Maqu_3562 | Maqu_2431 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.436 |