STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYP51Sterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24- methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol; Belongs to the cytochrome P450 family. (481 aa)    
Predicted Functional Partners:
Q4DZE6_TRYCC
Lanosterol synthase, putative; Belongs to the terpene cyclase/mutase family.
 
 0.999
Q4E2Y7_TRYCC
Lanosterol synthase, putative; Belongs to the terpene cyclase/mutase family.
 
 0.999
Q4E3K4_TRYCC
C-8 sterol isomerase, putative.
   
 
 0.999
Q4CWB4_TRYCC
Farnesyltransferase, putative.
 
 
 0.998
Q4CXF7_TRYCC
Farnesyltransferase, putative.
 
 
 0.998
Q4CV92_TRYCC
C-14 sterol reductase, putative.
   
 0.991
Q4D540_TRYCC
C-14 sterol reductase, putative.
   
 0.991
Q4CMP6_TRYCC
NAD(P)-dependent steroid dehydrogenase protein, putative.
  
 0.990
Q4D249_TRYCC
Epimerase domain-containing protein.
  
 0.988
Q4DW93_TRYCC
Epimerase domain-containing protein.
  
 0.988
Your Current Organism:
Trypanosoma cruzi
NCBI taxonomy Id: 353153
Other names: T. cruzi strain CL Brener, Trypanosoma cruzi strain CL Brener
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