node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABQ88998.1 | ABQ92255.1 | RoseRS_0576 | RoseRS_3902 | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase. | 0.615 |
ABQ88998.1 | hisA | RoseRS_0576 | RoseRS_3192 | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.885 |
ABQ88998.1 | hisB | RoseRS_0576 | RoseRS_1120 | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | PFAM: imidazoleglycerol-phosphate dehydratase. | 0.954 |
ABQ88998.1 | hisD | RoseRS_0576 | RoseRS_3179 | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.950 |
ABQ88998.1 | hisF | RoseRS_0576 | RoseRS_3194 | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.916 |
ABQ88998.1 | hisG | RoseRS_0576 | RoseRS_3180 | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.925 |
ABQ88998.1 | hisH | RoseRS_0576 | RoseRS_3191 | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.930 |
ABQ88998.1 | hisI | RoseRS_0576 | RoseRS_0207 | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | PFAM: phosphoribosyl-AMP cyclohydrolase; MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.984 |
ABQ92255.1 | ABQ88998.1 | RoseRS_3902 | RoseRS_0576 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase. | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | 0.615 |
ABQ92255.1 | hisA | RoseRS_3902 | RoseRS_3192 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.825 |
ABQ92255.1 | hisB | RoseRS_3902 | RoseRS_1120 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase. | PFAM: imidazoleglycerol-phosphate dehydratase. | 0.828 |
ABQ92255.1 | hisC | RoseRS_3902 | RoseRS_3872 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase. | Aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.615 |
ABQ92255.1 | hisD | RoseRS_3902 | RoseRS_3179 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.704 |
ABQ92255.1 | hisF | RoseRS_3902 | RoseRS_3194 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.855 |
ABQ92255.1 | hisG | RoseRS_3902 | RoseRS_3180 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.562 |
ABQ92255.1 | hisH | RoseRS_3902 | RoseRS_3191 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.826 |
ABQ92255.1 | hisI | RoseRS_3902 | RoseRS_0207 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase. | PFAM: phosphoribosyl-AMP cyclohydrolase; MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.976 |
hisA | ABQ88998.1 | RoseRS_3192 | RoseRS_0576 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II. | 0.885 |
hisA | ABQ92255.1 | RoseRS_3192 | RoseRS_3902 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase. | 0.825 |
hisA | hisB | RoseRS_3192 | RoseRS_1120 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | PFAM: imidazoleglycerol-phosphate dehydratase. | 0.981 |