| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cphy_0002 | Cphy_0003 | Cphy_0002 | Cphy_0003 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | 0.852 |
| Cphy_0002 | Cphy_2365 | Cphy_0002 | Cphy_2365 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: amt:Amet_3681 hypothetical protein. | 0.923 |
| Cphy_0002 | dnaA | Cphy_0002 | Cphy_0001 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.980 |
| Cphy_0002 | gyrA | Cphy_0002 | Cphy_0006 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.552 |
| Cphy_0002 | gyrB | Cphy_0002 | Cphy_0005 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.761 |
| Cphy_0002 | recF | Cphy_0002 | Cphy_0004 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.883 |
| Cphy_0003 | Cphy_0002 | Cphy_0003 | Cphy_0002 | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.852 |
| Cphy_0003 | Cphy_1345 | Cphy_0003 | Cphy_1345 | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | 0.497 |
| Cphy_0003 | Cphy_2365 | Cphy_0003 | Cphy_2365 | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | KEGG: amt:Amet_3681 hypothetical protein. | 0.417 |
| Cphy_0003 | Cphy_3490 | Cphy_0003 | Cphy_3490 | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pfl:PFL_0077 zinc ABC transporter, ATP-binding protein. | 0.453 |
| Cphy_0003 | dnaA | Cphy_0003 | Cphy_0001 | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.645 |
| Cphy_0003 | gyrA | Cphy_0003 | Cphy_0006 | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.412 |
| Cphy_0003 | gyrB | Cphy_0003 | Cphy_0005 | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.432 |
| Cphy_0003 | recF | Cphy_0003 | Cphy_0004 | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.857 |
| Cphy_1345 | Cphy_0003 | Cphy_1345 | Cphy_0003 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | 0.497 |
| Cphy_1345 | gyrA | Cphy_1345 | Cphy_0006 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.682 |
| Cphy_2365 | Cphy_0002 | Cphy_2365 | Cphy_0002 | KEGG: amt:Amet_3681 hypothetical protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.923 |
| Cphy_2365 | Cphy_0003 | Cphy_2365 | Cphy_0003 | KEGG: amt:Amet_3681 hypothetical protein. | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | 0.417 |
| Cphy_2365 | recF | Cphy_2365 | Cphy_0004 | KEGG: amt:Amet_3681 hypothetical protein. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.553 |
| Cphy_3490 | Cphy_0003 | Cphy_3490 | Cphy_0003 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pfl:PFL_0077 zinc ABC transporter, ATP-binding protein. | PFAM: RNA-binding S4 domain protein; KEGG: art:Arth_1328 RNA-binding S4 domain protein. | 0.453 |
