node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAH43954.1 | BAH44367.1 | BBR47_29770 | BBR47_33900 | Probable acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 2-oxo acid oxidoreductase alpha subunit. | 0.905 |
BAH43954.1 | leuA | BBR47_29770 | BBR47_16210 | Probable acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.977 |
BAH44367.1 | BAH43954.1 | BBR47_33900 | BBR47_29770 | 2-oxo acid oxidoreductase alpha subunit. | Probable acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 0.905 |
BAH44367.1 | ilvB | BBR47_33900 | BBR47_16180 | 2-oxo acid oxidoreductase alpha subunit. | Acetolactate synthase large subunit. | 0.951 |
BAH44367.1 | ilvC | BBR47_33900 | BBR47_16200 | 2-oxo acid oxidoreductase alpha subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.465 |
BAH44367.1 | ilvH | BBR47_33900 | BBR47_16190 | 2-oxo acid oxidoreductase alpha subunit. | Acetolactate synthase small subunit. | 0.937 |
BAH44367.1 | leuA | BBR47_33900 | BBR47_16210 | 2-oxo acid oxidoreductase alpha subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.940 |
BAH44367.1 | leuC | BBR47_33900 | BBR47_25330 | 2-oxo acid oxidoreductase alpha subunit. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.824 |
BAH44367.1 | leuD | BBR47_33900 | BBR47_25320 | 2-oxo acid oxidoreductase alpha subunit. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.808 |
ilvB | BAH44367.1 | BBR47_16180 | BBR47_33900 | Acetolactate synthase large subunit. | 2-oxo acid oxidoreductase alpha subunit. | 0.951 |
ilvB | ilvC | BBR47_16180 | BBR47_16200 | Acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
ilvB | ilvD | BBR47_16180 | BBR47_42770 | Acetolactate synthase large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.976 |
ilvB | ilvE | BBR47_16180 | BBR47_15810 | Acetolactate synthase large subunit. | Branched-chain amino acid aminotransferase. | 0.527 |
ilvB | ilvH | BBR47_16180 | BBR47_16190 | Acetolactate synthase large subunit. | Acetolactate synthase small subunit. | 0.999 |
ilvB | leuA | BBR47_16180 | BBR47_16210 | Acetolactate synthase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.979 |
ilvB | leuB | BBR47_16180 | BBR47_16220 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.989 |
ilvB | leuC | BBR47_16180 | BBR47_25330 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.810 |
ilvB | leuD | BBR47_16180 | BBR47_25320 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.839 |
ilvC | BAH44367.1 | BBR47_16200 | BBR47_33900 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-oxo acid oxidoreductase alpha subunit. | 0.465 |
ilvC | ilvB | BBR47_16200 | BBR47_16180 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase large subunit. | 0.998 |