fhs protein (Agrobacterium rhizogenes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

fhs

Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the formate--tetrahydrofolate ligase family (559 aa)

Predicted Functional Partners:

gcvP

0.999

CN09_23555

0.992

putA

0.963

nnrD

0.963

CN09_04750

0.951

gcvH

0.912

guaA

0.899

CN09_17085

0.899

ndk

0.895

glyA

0.892

Your Current Organism:

Agrobacterium rhizogenes

NCBI taxonomy Id: 359
Other names: A. rhizogenes, ATCC 11325, Agrobacterium biovar 2, Agrobacterium genomic group 10, Agrobacterium genomic species 10, Agrobacterium genomosp. 10, Agrobacterium rhizogenes, Agrobacterium rhizogenes (RI plasmid PRI1724), Agrobacterium rhizogenes (RI plasmid PRI8196), Agrobacterium rhizogenes (RI plasmid PRIA4B), CFBP 5520, CIP 104328, DSM 30148, ICMP 5794, IFO 13257, JCM 20919, LMG 150, NBRC 13257, NCPPB 2991, Rhizobium rhizogenes, Rhizobium sp. LMG 9509

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CN09_04750	CN09_17085	CN09_04750	CN09_17085	Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Pyruvate, phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the PEP-utilizing enzyme family	0.999
CN09_04750	CN09_23555	CN09_04750	CN09_23555	Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Ferredoxin; Derived by automated computational analysis using gene prediction method- Protein Homology	0.944
CN09_04750	fhs	CN09_04750	CN09_03965	Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the formate--tetrahydrofolate ligase family	0.951
CN09_04750	gcvH	CN09_04750	CN09_06890	Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	0.945
CN09_04750	gcvP	CN09_04750	CN09_06885	Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family	0.999
CN09_04750	glyA	CN09_04750	CN09_10385	Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	0.877
CN09_04750	guaA	CN09_04750	CN09_14055	Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	0.864
CN09_04750	ndk	CN09_04750	CN09_10590	Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	0.615
CN09_04750	nnrD	CN09_04750	CN09_07485	Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Multifunctional fusion protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration; Belongs to the NnrD/CARKD family	0.999
CN09_17085	CN09_04750	CN09_17085	CN09_04750	Pyruvate, phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the PEP-utilizing enzyme family	Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	0.999
CN09_17085	CN09_23555	CN09_17085	CN09_23555	Pyruvate, phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the PEP-utilizing enzyme family	Ferredoxin; Derived by automated computational analysis using gene prediction method- Protein Homology	0.999
CN09_17085	fhs	CN09_17085	CN09_03965	Pyruvate, phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the PEP-utilizing enzyme family	Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the formate--tetrahydrofolate ligase family	0.899
CN09_17085	glyA	CN09_17085	CN09_10385	Pyruvate, phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the PEP-utilizing enzyme family	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	0.872
CN09_17085	guaA	CN09_17085	CN09_14055	Pyruvate, phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the PEP-utilizing enzyme family	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	0.999
CN09_23555	CN09_04750	CN09_23555	CN09_04750	Ferredoxin; Derived by automated computational analysis using gene prediction method- Protein Homology	Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	0.944
CN09_23555	CN09_17085	CN09_23555	CN09_17085	Ferredoxin; Derived by automated computational analysis using gene prediction method- Protein Homology	Pyruvate, phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the PEP-utilizing enzyme family	0.999
CN09_23555	fhs	CN09_23555	CN09_03965	Ferredoxin; Derived by automated computational analysis using gene prediction method- Protein Homology	Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the formate--tetrahydrofolate ligase family	0.992
CN09_23555	gcvH	CN09_23555	CN09_06890	Ferredoxin; Derived by automated computational analysis using gene prediction method- Protein Homology	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	0.424
CN09_23555	gcvP	CN09_23555	CN09_06885	Ferredoxin; Derived by automated computational analysis using gene prediction method- Protein Homology	Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family	0.875
CN09_23555	glyA	CN09_23555	CN09_10385	Ferredoxin; Derived by automated computational analysis using gene prediction method- Protein Homology	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	0.873

page 1 of 4

Network

Neighborhood

Experiments

Fusion

Textmining

Cooccurrence

Databases

Coexpression

© STRING Consortium 2020

Credits

Access

Info

About