CN09_05380 protein (Agrobacterium rhizogenes)

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CN09_05380

Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (172 aa)

Predicted Functional Partners:

thyA

0.999

CN09_06460

0.938

purK

0.928

polA

0.910

CN09_06470

0.902

CN09_05390

0.884

CN09_03985

0.869

CN09_05385

0.865

CN09_10375

0.837

CN09_16240

0.812

Your Current Organism:

Agrobacterium rhizogenes

NCBI taxonomy Id: 359
Other names: A. rhizogenes, ATCC 11325, Agrobacterium biovar 2, Agrobacterium genomic group 10, Agrobacterium genomic species 10, Agrobacterium genomosp. 10, Agrobacterium rhizogenes, Agrobacterium rhizogenes (RI plasmid PRI1724), Agrobacterium rhizogenes (RI plasmid PRI8196), Agrobacterium rhizogenes (RI plasmid PRIA4B), CFBP 5520, CIP 104328, DSM 30148, ICMP 5794, IFO 13257, JCM 20919, LMG 150, NBRC 13257, NCPPB 2991, Rhizobium rhizogenes, Rhizobium sp. LMG 9509

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CN09_03985	CN09_05380	CN09_03985	CN09_05380	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	0.869
CN09_03985	CN09_06460	CN09_03985	CN09_06460	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	0.999
CN09_03985	CN09_06470	CN09_03985	CN09_06470	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method- Protein Homology	0.999
CN09_03985	CN09_10375	CN09_03985	CN09_10375	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5’-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5’-phosphate; In the C-terminal section; belongs to the HTP reductase family	0.999
CN09_03985	polA	CN09_03985	CN09_13050	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.999
CN09_03985	purK	CN09_03985	CN09_02060	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	0.850
CN09_03985	thyA	CN09_03985	CN09_05290	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	0.950
CN09_05380	CN09_03985	CN09_05380	CN09_03985	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	0.869
CN09_05380	CN09_05385	CN09_05380	CN09_05385	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	Protein HflK; HflC and HflK could encode or regulate a protease	0.865
CN09_05380	CN09_05390	CN09_05380	CN09_05390	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	Protein HflC; HflC and HflK could regulate a protease	0.884
CN09_05380	CN09_06460	CN09_05380	CN09_06460	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	0.938
CN09_05380	CN09_06470	CN09_05380	CN09_06470	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method- Protein Homology	0.902
CN09_05380	CN09_10375	CN09_05380	CN09_10375	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5’-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5’-phosphate; In the C-terminal section; belongs to the HTP reductase family	0.837
CN09_05380	CN09_16240	CN09_05380	CN09_16240	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	Riboflavin biosynthesis protein; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the ribF family	0.812
CN09_05380	polA	CN09_05380	CN09_13050	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.910
CN09_05380	purK	CN09_05380	CN09_02060	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	0.928
CN09_05380	thyA	CN09_05380	CN09_05290	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	0.999
CN09_05385	CN09_05380	CN09_05385	CN09_05380	Protein HflK; HflC and HflK could encode or regulate a protease	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	0.865
CN09_05385	CN09_05390	CN09_05385	CN09_05390	Protein HflK; HflC and HflK could encode or regulate a protease	Protein HflC; HflC and HflK could regulate a protease	0.999
CN09_05385	polA	CN09_05385	CN09_13050	Protein HflK; HflC and HflK could encode or regulate a protease	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.478

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