node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CN09_05380 | CN09_05390 | CN09_05380 | CN09_05390 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Membrane protein; HflC and HflK could regulate a protease | 0.893 |
CN09_05380 | CN09_15290 | CN09_05380 | CN09_15290 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Hemagglutinin; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.795 |
CN09_05380 | CN09_16240 | CN09_05380 | CN09_16240 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Riboflavin kinase; Belongs to the ribF family | 0.813 |
CN09_05380 | folE | CN09_05380 | CN09_07085 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | GTP cyclohydrolase 1; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.826 |
CN09_05380 | folK | CN09_05380 | CN09_06470 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.853 |
CN09_05380 | folP | CN09_05380 | CN09_06460 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives | 0.943 |
CN09_05380 | hflK | CN09_05380 | CN09_05385 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Hypothetical protein; HflC and HflK could encode or regulate a protease | 0.876 |
CN09_05380 | purK | CN09_05380 | CN09_02060 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) | 0.932 |
CN09_05380 | ribD | CN09_05380 | CN09_10375 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate | 0.999 |
CN09_05380 | thyA | CN09_05380 | CN09_05290 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.999 |
CN09_05390 | CN09_05380 | CN09_05390 | CN09_05380 | Membrane protein; HflC and HflK could regulate a protease | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 0.893 |
CN09_05390 | hflK | CN09_05390 | CN09_05385 | Membrane protein; HflC and HflK could regulate a protease | Hypothetical protein; HflC and HflK could encode or regulate a protease | 0.999 |
CN09_05390 | thyA | CN09_05390 | CN09_05290 | Membrane protein; HflC and HflK could regulate a protease | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.789 |
CN09_15290 | CN09_05380 | CN09_15290 | CN09_05380 | Hemagglutinin; Derived by automated computational analysis using gene prediction method: Protein Homology | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 0.795 |
CN09_15290 | CN09_16240 | CN09_15290 | CN09_16240 | Hemagglutinin; Derived by automated computational analysis using gene prediction method: Protein Homology | Riboflavin kinase; Belongs to the ribF family | 0.999 |
CN09_15290 | folE | CN09_15290 | CN09_07085 | Hemagglutinin; Derived by automated computational analysis using gene prediction method: Protein Homology | GTP cyclohydrolase 1; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.731 |
CN09_15290 | folP | CN09_15290 | CN09_06460 | Hemagglutinin; Derived by automated computational analysis using gene prediction method: Protein Homology | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives | 0.780 |
CN09_15290 | ribD | CN09_15290 | CN09_10375 | Hemagglutinin; Derived by automated computational analysis using gene prediction method: Protein Homology | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate | 0.999 |
CN09_15290 | thyA | CN09_15290 | CN09_05290 | Hemagglutinin; Derived by automated computational analysis using gene prediction method: Protein Homology | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.902 |
CN09_16240 | CN09_05380 | CN09_16240 | CN09_05380 | Riboflavin kinase; Belongs to the ribF family | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 0.813 |