node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CN09_05380 | CN09_05385 | CN09_05380 | CN09_05385 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Protein HflK; HflC and HflK could encode or regulate a protease | 0.865 |
CN09_05380 | CN09_05390 | CN09_05380 | CN09_05390 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Protein HflC; HflC and HflK could regulate a protease | 0.884 |
CN09_05380 | thyA | CN09_05380 | CN09_05290 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.999 |
CN09_05385 | CN09_05380 | CN09_05385 | CN09_05380 | Protein HflK; HflC and HflK could encode or regulate a protease | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 0.865 |
CN09_05385 | CN09_05390 | CN09_05385 | CN09_05390 | Protein HflK; HflC and HflK could encode or regulate a protease | Protein HflC; HflC and HflK could regulate a protease | 0.999 |
CN09_05385 | CN09_06270 | CN09_05385 | CN09_06270 | Protein HflK; HflC and HflK could encode or regulate a protease | Glutathione reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family | 0.771 |
CN09_05385 | ctaG | CN09_05385 | CN09_16850 | Protein HflK; HflC and HflK could encode or regulate a protease | Cytochrome c oxidase assembly protein CtaG; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I | 0.792 |
CN09_05385 | hflX | CN09_05385 | CN09_07725 | Protein HflK; HflC and HflK could encode or regulate a protease | GTPase HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis | 0.974 |
CN09_05385 | htpG | CN09_05385 | CN09_32535 | Protein HflK; HflC and HflK could encode or regulate a protease | Chaperone protein HtpG; Molecular chaperone. Has ATPase activity | 0.846 |
CN09_05385 | miaA | CN09_05385 | CN09_05410 | Protein HflK; HflC and HflK could encode or regulate a protease | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family | 0.966 |
CN09_05385 | nnrD | CN09_05385 | CN09_07485 | Protein HflK; HflC and HflK could encode or regulate a protease | Multifunctional fusion protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration; Belongs to the NnrD/CARKD family | 0.812 |
CN09_05385 | rnc | CN09_05385 | CN09_10985 | Protein HflK; HflC and HflK could encode or regulate a protease | Ribonuclease 3; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism | 0.785 |
CN09_05385 | thyA | CN09_05385 | CN09_05290 | Protein HflK; HflC and HflK could encode or regulate a protease | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.765 |
CN09_05390 | CN09_05380 | CN09_05390 | CN09_05380 | Protein HflC; HflC and HflK could regulate a protease | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 0.884 |
CN09_05390 | CN09_05385 | CN09_05390 | CN09_05385 | Protein HflC; HflC and HflK could regulate a protease | Protein HflK; HflC and HflK could encode or regulate a protease | 0.999 |
CN09_05390 | CN09_06270 | CN09_05390 | CN09_06270 | Protein HflC; HflC and HflK could regulate a protease | Glutathione reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family | 0.771 |
CN09_05390 | ctaG | CN09_05390 | CN09_16850 | Protein HflC; HflC and HflK could regulate a protease | Cytochrome c oxidase assembly protein CtaG; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I | 0.785 |
CN09_05390 | hflX | CN09_05390 | CN09_07725 | Protein HflC; HflC and HflK could regulate a protease | GTPase HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis | 0.972 |
CN09_05390 | htpG | CN09_05390 | CN09_32535 | Protein HflC; HflC and HflK could regulate a protease | Chaperone protein HtpG; Molecular chaperone. Has ATPase activity | 0.844 |
CN09_05390 | miaA | CN09_05390 | CN09_05410 | Protein HflC; HflC and HflK could regulate a protease | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family | 0.958 |