node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CN09_06645 | purL | CN09_06645 | CN09_06650 | Transcriptional regulator; Belongs to the BolA/IbaG family | Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from Pu [...] | 0.999 |
CN09_06645 | purQ | CN09_06645 | CN09_06680 | Transcriptional regulator; Belongs to the BolA/IbaG family | Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from Pu [...] | 0.756 |
CN09_17085 | addB | CN09_17085 | CN09_17570 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.864 |
CN09_17085 | guaA | CN09_17085 | CN09_14055 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | Gmp synthase; Catalyzes the synthesis of GMP from XMP | 0.999 |
CN09_17085 | guaB | CN09_17085 | CN09_16005 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.908 |
CN09_17085 | ispDF | CN09_17085 | CN09_07765 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) | 0.997 |
CN09_17085 | purE | CN09_17085 | CN09_02065 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) | 0.449 |
CN09_17085 | purL | CN09_17085 | CN09_06650 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from Pu [...] | 0.999 |
CN09_17085 | purQ | CN09_17085 | CN09_06680 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from Pu [...] | 0.717 |
addB | CN09_17085 | CN09_17570 | CN09_17085 | Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | 0.864 |
addB | guaA | CN09_17570 | CN09_14055 | Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology | Gmp synthase; Catalyzes the synthesis of GMP from XMP | 0.807 |
addB | purL | CN09_17570 | CN09_06650 | Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology | Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from Pu [...] | 0.999 |
guaA | CN09_17085 | CN09_14055 | CN09_17085 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | 0.999 |
guaA | addB | CN09_14055 | CN09_17570 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.807 |
guaA | guaB | CN09_14055 | CN09_16005 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.999 |
guaA | ispDF | CN09_14055 | CN09_07765 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) | 0.768 |
guaA | nnrD | CN09_14055 | CN09_07485 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | Hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.743 |
guaA | purD | CN09_14055 | CN09_16590 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | Phosphoribosylamine--glycine ligase; Belongs to the GARS family | 0.999 |
guaA | purE | CN09_14055 | CN09_02065 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) | 0.999 |
guaA | purL | CN09_14055 | CN09_06650 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from Pu [...] | 0.999 |