parC protein (Agrobacterium rhizogenes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

parC

DNA topoisomerase 4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily (752 aa)

Predicted Functional Partners:

parE

0.995

gyrB

0.980

pheT

0.963

CN09_01825

0.951

CN09_03985

0.949

CN09_06240

0.930

topA

0.901

polA

0.886

guaA

0.848

CN09_17085

0.846

Your Current Organism:

Agrobacterium rhizogenes

NCBI taxonomy Id: 359
Other names: A. rhizogenes, ATCC 11325, Agrobacterium biovar 2, Agrobacterium genomic group 10, Agrobacterium genomic species 10, Agrobacterium genomosp. 10, Agrobacterium rhizogenes, Agrobacterium rhizogenes (RI plasmid PRI1724), Agrobacterium rhizogenes (RI plasmid PRI8196), Agrobacterium rhizogenes (RI plasmid PRIA4B), CFBP 5520, CIP 104328, DSM 30148, ICMP 5794, IFO 13257, JCM 20919, LMG 150, NBRC 13257, NCPPB 2991, Rhizobium rhizogenes, Rhizobium sp. LMG 9509

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CN09_01825	CN09_03985	CN09_01825	CN09_03985	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	0.999
CN09_01825	CN09_06240	CN09_01825	CN09_06240	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)- malate; Belongs to the class-I fumarase family	0.412
CN09_01825	CN09_17085	CN09_01825	CN09_17085	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Pyruvate, phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the PEP-utilizing enzyme family	0.922
CN09_01825	guaA	CN09_01825	CN09_14055	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	0.999
CN09_01825	gyrB	CN09_01825	CN09_17645	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	0.999
CN09_01825	parC	CN09_01825	CN09_10440	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	DNA topoisomerase 4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily	0.951
CN09_01825	parE	CN09_01825	CN09_07150	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	DNA topoisomerase 4 subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily	0.999
CN09_01825	pheT	CN09_01825	CN09_13825	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	Phenylalanine--tRNA ligase beta subunit; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	0.869
CN09_01825	polA	CN09_01825	CN09_13050	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.983
CN09_01825	topA	CN09_01825	CN09_09825	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA super [...]	0.945
CN09_03985	CN09_01825	CN09_03985	CN09_01825	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	0.999
CN09_03985	CN09_06240	CN09_03985	CN09_06240	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)- malate; Belongs to the class-I fumarase family	0.873
CN09_03985	CN09_17085	CN09_03985	CN09_17085	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	Pyruvate, phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the PEP-utilizing enzyme family	0.999
CN09_03985	guaA	CN09_03985	CN09_14055	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	0.571
CN09_03985	parC	CN09_03985	CN09_10440	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	DNA topoisomerase 4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily	0.949
CN09_03985	pheT	CN09_03985	CN09_13825	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	Phenylalanine--tRNA ligase beta subunit; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	0.990
CN09_03985	polA	CN09_03985	CN09_13050	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.999
CN09_06240	CN09_01825	CN09_06240	CN09_01825	Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)- malate; Belongs to the class-I fumarase family	Glutamate synthase; Derived by automated computational analysis using gene prediction method- Protein Homology	0.412
CN09_06240	CN09_03985	CN09_06240	CN09_03985	Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)- malate; Belongs to the class-I fumarase family	Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method- Protein Homology	0.873
CN09_06240	CN09_17085	CN09_06240	CN09_17085	Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)- malate; Belongs to the class-I fumarase family	Pyruvate, phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the PEP-utilizing enzyme family	0.976

page 1 of 5

Network

Neighborhood

Experiments

Fusion

Textmining

Cooccurrence

Databases

Coexpression

© STRING Consortium 2020

Credits

Access

Info

About