node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CN09_06240 | gyrA | CN09_06240 | CN09_07460 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate | Dna gyrase subunit a; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.930 |
CN09_06240 | gyrB | CN09_06240 | CN09_17645 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate | Dna gyrase subunit b; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.826 |
CN09_06240 | parC | CN09_06240 | CN09_10440 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.930 |
CN09_06240 | parE | CN09_06240 | CN09_07150 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate | Dna topoisomerase iv subunit b; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.826 |
gltB | guaA | CN09_01825 | CN09_14055 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology | Gmp synthase; Catalyzes the synthesis of GMP from XMP | 0.999 |
gltB | gyrA | CN09_01825 | CN09_07460 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology | Dna gyrase subunit a; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.999 |
gltB | gyrB | CN09_01825 | CN09_17645 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology | Dna gyrase subunit b; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.999 |
gltB | parC | CN09_01825 | CN09_10440 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.999 |
gltB | parE | CN09_01825 | CN09_07150 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology | Dna topoisomerase iv subunit b; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.999 |
gltB | pheT | CN09_01825 | CN09_13825 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology | Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily | 0.999 |
gltB | polA | CN09_01825 | CN09_13050 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology | In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.999 |
gltB | rpoB | CN09_01825 | CN09_08935 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology | Dna-directed rna polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates | 0.999 |
gltB | topA | CN09_01825 | CN09_09825 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology | Dna topoisomerase i; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.945 |
guaA | gltB | CN09_14055 | CN09_01825 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.999 |
guaA | gyrA | CN09_14055 | CN09_07460 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | Dna gyrase subunit a; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.999 |
guaA | gyrB | CN09_14055 | CN09_17645 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | Dna gyrase subunit b; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.999 |
guaA | parC | CN09_14055 | CN09_10440 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.999 |
guaA | parE | CN09_14055 | CN09_07150 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | Dna topoisomerase iv subunit b; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.999 |
guaA | pheT | CN09_14055 | CN09_13825 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily | 0.999 |
guaA | polA | CN09_14055 | CN09_13050 | Gmp synthase; Catalyzes the synthesis of GMP from XMP | In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.999 |