STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gltACitrate synthase; Belongs to the citrate synthase family. (430 aa)    
Predicted Functional Partners:
sucC
Succinate--CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.995
mdh
Lactate/malate dehydrogenase:L-lactate dehydrogenase:TrkA potassium uptake protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.995
BAB1_0090
Aconitate hydratase, C-terminal:Aconitate hydratase, N-terminal:Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.992
BAB1_1900
4Fe-4S ferredoxin, iron-sulfur binding domain:Succinate dehydrogenase/fumarate reductase iron-sulfur protein:2Fe-2S ferredoxin.
  
 0.969
BAB1_1901
Succinate dehydrogenase flavoprotein subunit; FAD-dependent pyridine nucleotide-disulphide oxidoreductase:Fumarate reductase/succinate dehydrogenase, FAD-binding site:Fuma..; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 0.963
BAB1_0977
Hypothetical; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.959
BAB1_1221
Isocitrate/isopropylmalate dehydrogenase:Isocitrate dehydrogenase NADP-dependent, eukaryotic; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 
 0.956
sucD
Hypothetical; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.931
BAB2_1042
Alpha/beta hydrolase fold:Biotin/lipoyl attachment:Esterase/lipase/thioesterase, active site:2-oxo acid dehydrogenase, acyltr.
  
 0.926
sucA
Dehydrogenase, E1 component:Transketolase, central region; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
  
 
 0.912
Your Current Organism:
Brucella abortus
NCBI taxonomy Id: 359391
Other names: B. abortus 2308, Brucella abortus 2308, Brucella melitensis biovar Abortus 2308
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