STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (321 aa)    
Predicted Functional Partners:
gltA
Citrate synthase I; Identified by match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family.
  
 0.992
dme
NAD-dependent malic enzyme; Identified by similarity to SP:O30807; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.
  
 0.973
ABM44440.1
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF03949.
  
 0.973
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.970
aatA
Aspartate aminotransferase; Identified by similarity to SP:Q02635; match to protein family HMM PF00155.
  
 0.941
ABM45178.1
Isocitrate dehydrogenase, NADP-dependent; Identified by similarity to SP:P50215; match to protein family HMM PF00180; match to protein family HMM TIGR00127; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 
 0.922
sucD
succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.906
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.884
gap
Glyceraldehyde-3-phosphate dehydrogenase, type I; Identified by similarity to SP:P51009; match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  
 
 0.860
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
  
 0.851
Your Current Organism:
Bartonella bacilliformis KC583
NCBI taxonomy Id: 360095
Other names: B. bacilliformis KC583, Bartonella bacilliformis str. KC583, Bartonella bacilliformis strain KC583
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