STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (611 aa)    
Predicted Functional Partners:
thiD
Phosphomethylpyrimidine kinase; Identified by similarity to SP:P56904; match to protein family HMM PF01256; match to protein family HMM PF08543.
  
 
 0.996
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
  
 0.974
thiS
Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683.
  
    0.957
thiE
Thiamine-phosphate pyrophosphorylase; Identified by similarity to SP:O34294; match to protein family HMM PF02581; match to protein family HMM TIGR00693.
  
  
 0.949
ABM44665.1
Thiamine biosynthesis oxidoreductase; Identified by match to protein family HMM PF01266; match to protein family HMM TIGR02352.
  
  
 0.811
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
     
  0.800
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Identified by match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR00878.
     
  0.800
ABM44921.1
Identified by match to protein family HMM PF02581; match to protein family HMM TIGR00693.
  
  
 0.775
ABM45259.1
ThiF/MoeZ/MoeB domain protein; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237; match to protein family HMM TIGR02354; match to protein family HMM TIGR02356.
  
  
 0.774
ribD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
      
 0.499
Your Current Organism:
Bartonella bacilliformis KC583
NCBI taxonomy Id: 360095
Other names: B. bacilliformis KC583, Bartonella bacilliformis str. KC583, Bartonella bacilliformis strain KC583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.