node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABM45001.1 | folE | BARBAKC583_0642 | BARBAKC583_0644 | Conserved hypothetical protein TIGR00278; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | 0.573 |
ABM45001.1 | ispDF | BARBAKC583_0642 | BARBAKC583_0540 | Conserved hypothetical protein TIGR00278; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | IspD/IspF bifunctional enzyme; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.431 |
dnaK | folE | BARBAKC583_1328 | BARBAKC583_0644 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | 0.633 |
dnaK | hflB | BARBAKC583_1328 | BARBAKC583_0168 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.642 |
dnaK | nadE | BARBAKC583_1328 | BARBAKC583_0606 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.508 |
dnaK | ndk | BARBAKC583_1328 | BARBAKC583_0514 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.632 |
folC | folE | BARBAKC583_1352 | BARBAKC583_0644 | Folylpolyglutamate synthase; Identified by match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | 0.579 |
folC | ispDF | BARBAKC583_1352 | BARBAKC583_0540 | Folylpolyglutamate synthase; Identified by match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | IspD/IspF bifunctional enzyme; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.606 |
folC | nadE | BARBAKC583_1352 | BARBAKC583_0606 | Folylpolyglutamate synthase; Identified by match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.551 |
folC | ribBA | BARBAKC583_1352 | BARBAKC583_0398 | Folylpolyglutamate synthase; Identified by match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.507 |
folC | ribD | BARBAKC583_1352 | BARBAKC583_0631 | Folylpolyglutamate synthase; Identified by match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.605 |
folE | ABM45001.1 | BARBAKC583_0644 | BARBAKC583_0642 | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | Conserved hypothetical protein TIGR00278; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.573 |
folE | dnaK | BARBAKC583_0644 | BARBAKC583_1328 | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.633 |
folE | folC | BARBAKC583_0644 | BARBAKC583_1352 | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | Folylpolyglutamate synthase; Identified by match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.579 |
folE | hflB | BARBAKC583_0644 | BARBAKC583_0168 | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.638 |
folE | ispDF | BARBAKC583_0644 | BARBAKC583_0540 | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | IspD/IspF bifunctional enzyme; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.604 |
folE | nadE | BARBAKC583_0644 | BARBAKC583_0606 | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.589 |
folE | ndk | BARBAKC583_0644 | BARBAKC583_0514 | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.830 |
folE | relA | BARBAKC583_0644 | BARBAKC583_0468 | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.800 |
folE | ribBA | BARBAKC583_0644 | BARBAKC583_0398 | GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.950 |