node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABM44440.1 | asd | BARBAKC583_1298 | BARBAKC583_1101 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF03949. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.417 |
ABM44440.1 | dme | BARBAKC583_1298 | BARBAKC583_0622 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF03949. | NAD-dependent malic enzyme; Identified by similarity to SP:O30807; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949. | 0.946 |
ABM44440.1 | ilvC | BARBAKC583_1298 | BARBAKC583_0917 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF03949. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.489 |
ABM44440.1 | ilvE | BARBAKC583_1298 | BARBAKC583_0747 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF03949. | Branched-chain amino acid aminotransferase; Identified by match to protein family HMM PF01063; match to protein family HMM TIGR01123. | 0.416 |
ABM44440.1 | pdhB | BARBAKC583_1298 | BARBAKC583_0535 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF03949. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.992 |
argC | asd | BARBAKC583_0628 | BARBAKC583_1101 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.442 |
argC | ilvC | BARBAKC583_0628 | BARBAKC583_0917 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.471 |
argC | ribD | BARBAKC583_0628 | BARBAKC583_0631 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.436 |
asd | ABM44440.1 | BARBAKC583_1101 | BARBAKC583_1298 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF03949. | 0.417 |
asd | argC | BARBAKC583_1101 | BARBAKC583_0628 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. | 0.442 |
asd | dme | BARBAKC583_1101 | BARBAKC583_0622 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | NAD-dependent malic enzyme; Identified by similarity to SP:O30807; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949. | 0.417 |
asd | guaA | BARBAKC583_1101 | BARBAKC583_0344 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.528 |
asd | guaB | BARBAKC583_1101 | BARBAKC583_0341 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.542 |
asd | ilvC | BARBAKC583_1101 | BARBAKC583_0917 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.505 |
dme | ABM44440.1 | BARBAKC583_0622 | BARBAKC583_1298 | NAD-dependent malic enzyme; Identified by similarity to SP:O30807; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949. | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF03949. | 0.946 |
dme | asd | BARBAKC583_0622 | BARBAKC583_1101 | NAD-dependent malic enzyme; Identified by similarity to SP:O30807; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.417 |
dme | ilvC | BARBAKC583_0622 | BARBAKC583_0917 | NAD-dependent malic enzyme; Identified by similarity to SP:O30807; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.489 |
dme | ilvE | BARBAKC583_0622 | BARBAKC583_0747 | NAD-dependent malic enzyme; Identified by similarity to SP:O30807; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949. | Branched-chain amino acid aminotransferase; Identified by match to protein family HMM PF01063; match to protein family HMM TIGR01123. | 0.416 |
dme | pdhB | BARBAKC583_0622 | BARBAKC583_0535 | NAD-dependent malic enzyme; Identified by similarity to SP:O30807; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.992 |
guaA | asd | BARBAKC583_0344 | BARBAKC583_1101 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.528 |