node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAT97315.1 | folD | CCC13826_1310 | CCC13826_0832 | 5,10-methenyltetrahydrofolate synthetase; Pfam match to PF01812.15 5-FTHF_cyc-lig; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.940 |
EAT97315.1 | glyA | CCC13826_1310 | CCC13826_0226 | 5,10-methenyltetrahydrofolate synthetase; Pfam match to PF01812.15 5-FTHF_cyc-lig; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.469 |
EAT97315.1 | purN | CCC13826_1310 | CCC13826_1786 | 5,10-methenyltetrahydrofolate synthetase; Pfam match to PF01812.15 5-FTHF_cyc-lig; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.914 |
EAT99048.1 | fhs | CCC13826_1834 | CCC13826_1498 | Methylenetetrahydrofolate reductase family protein; Pfam match to PF02219.12 MTHFR; Belongs to the methylenetetrahydrofolate reductase family. | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.441 |
EAT99048.1 | folD | CCC13826_1834 | CCC13826_0832 | Methylenetetrahydrofolate reductase family protein; Pfam match to PF02219.12 MTHFR; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.940 |
EAT99048.1 | glyA | CCC13826_1834 | CCC13826_0226 | Methylenetetrahydrofolate reductase family protein; Pfam match to PF02219.12 MTHFR; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
EAT99048.1 | purH | CCC13826_1834 | CCC13826_1632 | Methylenetetrahydrofolate reductase family protein; Pfam match to PF02219.12 MTHFR; Belongs to the methylenetetrahydrofolate reductase family. | AICAR transformylase / IMP cyclohydrolase; Bifunctional; Pfam matches to PF01808.13 AICARFT_IMPCHas, and to PF02142.17 MGS. | 0.425 |
EAT99048.1 | purN | CCC13826_1834 | CCC13826_1786 | Methylenetetrahydrofolate reductase family protein; Pfam match to PF02219.12 MTHFR; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.419 |
EAT99048.1 | thyX | CCC13826_1834 | CCC13826_1861 | Methylenetetrahydrofolate reductase family protein; Pfam match to PF02219.12 MTHFR; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.908 |
fhs | EAT99048.1 | CCC13826_1498 | CCC13826_1834 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate reductase family protein; Pfam match to PF02219.12 MTHFR; Belongs to the methylenetetrahydrofolate reductase family. | 0.441 |
fhs | folD | CCC13826_1498 | CCC13826_0832 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | glyA | CCC13826_1498 | CCC13826_0226 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
fhs | purB | CCC13826_1498 | CCC13826_1894 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Pfam matches to PF00206.15 Lyase_1, and to PF10397.4 ADSL_C; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.560 |
fhs | purH | CCC13826_1498 | CCC13826_1632 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | AICAR transformylase / IMP cyclohydrolase; Bifunctional; Pfam matches to PF01808.13 AICARFT_IMPCHas, and to PF02142.17 MGS. | 0.988 |
fhs | purN | CCC13826_1498 | CCC13826_1786 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.970 |
fhs | thyX | CCC13826_1498 | CCC13826_1861 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.900 |
fmt | folD | CCC13826_0347 | CCC13826_0832 | 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.962 |
fmt | glyA | CCC13826_0347 | CCC13826_0226 | 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.911 |
fmt | purN | CCC13826_0347 | CCC13826_1786 | 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.912 |
fmt | thyX | CCC13826_0347 | CCC13826_1861 | 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.911 |