node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | guaB | CCC13826_1608 | CCC13826_0276 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.638 |
apt | purA | CCC13826_1608 | CCC13826_2131 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.512 |
apt | purB | CCC13826_1608 | CCC13826_1894 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Pfam matches to PF00206.15 Lyase_1, and to PF10397.4 ADSL_C; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.957 |
apt | purD | CCC13826_1608 | CCC13826_0492 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylamine-glycine ligase; Pfam matches to PF01071.14 GARS_A, and to PF02844.10 GARS_N, and to PF02843.11 GARS_C, and to PF13535.1 ATP-grasp_4, and to PF02655.9 ATP-grasp_3, and to PF02222.17 ATP-grasp, and to PF02786.12 CPSase_L_D2, and to PF08443.6 RimK; Belongs to the GARS family. | 0.459 |
apt | purH | CCC13826_1608 | CCC13826_1632 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | AICAR transformylase / IMP cyclohydrolase; Bifunctional; Pfam matches to PF01808.13 AICARFT_IMPCHas, and to PF02142.17 MGS. | 0.965 |
apt | purL | CCC13826_1608 | CCC13826_1628 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylformylglycinamidine synthase PurLQS, PurL subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is [...] | 0.464 |
apt | purN | CCC13826_1608 | CCC13826_1786 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.535 |
fhs | folD | CCC13826_1498 | CCC13826_0832 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | glyA | CCC13826_1498 | CCC13826_0226 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
fhs | guaB | CCC13826_1498 | CCC13826_0276 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.474 |
fhs | purB | CCC13826_1498 | CCC13826_1894 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Pfam matches to PF00206.15 Lyase_1, and to PF10397.4 ADSL_C; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.560 |
fhs | purD | CCC13826_1498 | CCC13826_0492 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine-glycine ligase; Pfam matches to PF01071.14 GARS_A, and to PF02844.10 GARS_N, and to PF02843.11 GARS_C, and to PF13535.1 ATP-grasp_4, and to PF02655.9 ATP-grasp_3, and to PF02222.17 ATP-grasp, and to PF02786.12 CPSase_L_D2, and to PF08443.6 RimK; Belongs to the GARS family. | 0.700 |
fhs | purH | CCC13826_1498 | CCC13826_1632 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | AICAR transformylase / IMP cyclohydrolase; Bifunctional; Pfam matches to PF01808.13 AICARFT_IMPCHas, and to PF02142.17 MGS. | 0.988 |
fhs | purL | CCC13826_1498 | CCC13826_1628 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine synthase PurLQS, PurL subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is [...] | 0.796 |
fhs | purN | CCC13826_1498 | CCC13826_1786 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.970 |
folD | fhs | CCC13826_0832 | CCC13826_1498 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.994 |
folD | glyA | CCC13826_0832 | CCC13826_0226 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.984 |
folD | guaB | CCC13826_0832 | CCC13826_0276 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.625 |
folD | purA | CCC13826_0832 | CCC13826_2131 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.734 |
folD | purB | CCC13826_0832 | CCC13826_1894 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Pfam matches to PF00206.15 Lyase_1, and to PF10397.4 ADSL_C; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.845 |