node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bamD | lon | CCC13826_1959 | CCC13826_1958 | Beta-barrel assembly machinery complex, BamD/YfiO lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | DNA-binding, ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.795 |
clpB | clpP | CCC13826_0095 | CCC13826_1781 | ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.9 AAA_2, and to PF10431.4 ClpB_D2-small, and to PF00004.24 AAA, and to PF07728.9 AAA_5, and to PF00004.24 AAA, and to PF02861.15 Clp_N, and to PF13191.1 AAA_16, and to PF13191.1 AAA_16; Belongs to the ClpA/ClpB family. | ATP-dependent ClpAP/ClpXP protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.978 |
clpB | dnaJ | CCC13826_0095 | CCC13826_0965 | ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.9 AAA_2, and to PF10431.4 ClpB_D2-small, and to PF00004.24 AAA, and to PF07728.9 AAA_5, and to PF00004.24 AAA, and to PF02861.15 Clp_N, and to PF13191.1 AAA_16, and to PF13191.1 AAA_16; Belongs to the ClpA/ClpB family. | DnaK system heat shock co-chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions be [...] | 0.789 |
clpB | dnaK | CCC13826_0095 | CCC13826_2046 | ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.9 AAA_2, and to PF10431.4 ClpB_D2-small, and to PF00004.24 AAA, and to PF07728.9 AAA_5, and to PF00004.24 AAA, and to PF02861.15 Clp_N, and to PF13191.1 AAA_16, and to PF13191.1 AAA_16; Belongs to the ClpA/ClpB family. | DnaK system heat shock chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.997 |
clpB | groEL | CCC13826_0095 | CCC13826_0667 | ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.9 AAA_2, and to PF10431.4 ClpB_D2-small, and to PF00004.24 AAA, and to PF07728.9 AAA_5, and to PF00004.24 AAA, and to PF02861.15 Clp_N, and to PF13191.1 AAA_16, and to PF13191.1 AAA_16; Belongs to the ClpA/ClpB family. | 60 kD chaperonin (cpn60); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.900 |
clpB | grpE | CCC13826_0095 | CCC13826_2045 | ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.9 AAA_2, and to PF10431.4 ClpB_D2-small, and to PF00004.24 AAA, and to PF07728.9 AAA_5, and to PF00004.24 AAA, and to PF02861.15 Clp_N, and to PF13191.1 AAA_16, and to PF13191.1 AAA_16; Belongs to the ClpA/ClpB family. | DnaK system nucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Se [...] | 0.927 |
clpB | hslU | CCC13826_0095 | CCC13826_1222 | ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.9 AAA_2, and to PF10431.4 ClpB_D2-small, and to PF00004.24 AAA, and to PF07728.9 AAA_5, and to PF00004.24 AAA, and to PF02861.15 Clp_N, and to PF13191.1 AAA_16, and to PF13191.1 AAA_16; Belongs to the ClpA/ClpB family. | Heat shock protein HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. | 0.726 |
clpB | hslV | CCC13826_0095 | CCC13826_1221 | ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.9 AAA_2, and to PF10431.4 ClpB_D2-small, and to PF00004.24 AAA, and to PF07728.9 AAA_5, and to PF00004.24 AAA, and to PF02861.15 Clp_N, and to PF13191.1 AAA_16, and to PF13191.1 AAA_16; Belongs to the ClpA/ClpB family. | Heat shock protein HslVU, ATP-dependent protease subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.639 |
clpB | htpG | CCC13826_0095 | CCC13826_1348 | ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.9 AAA_2, and to PF10431.4 ClpB_D2-small, and to PF00004.24 AAA, and to PF07728.9 AAA_5, and to PF00004.24 AAA, and to PF02861.15 Clp_N, and to PF13191.1 AAA_16, and to PF13191.1 AAA_16; Belongs to the ClpA/ClpB family. | Chaperone protein HtpG; Molecular chaperone. Has ATPase activity. | 0.957 |
clpB | lon | CCC13826_0095 | CCC13826_1958 | ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.9 AAA_2, and to PF10431.4 ClpB_D2-small, and to PF00004.24 AAA, and to PF07728.9 AAA_5, and to PF00004.24 AAA, and to PF02861.15 Clp_N, and to PF13191.1 AAA_16, and to PF13191.1 AAA_16; Belongs to the ClpA/ClpB family. | DNA-binding, ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.825 |
clpP | clpB | CCC13826_1781 | CCC13826_0095 | ATP-dependent ClpAP/ClpXP protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.9 AAA_2, and to PF10431.4 ClpB_D2-small, and to PF00004.24 AAA, and to PF07728.9 AAA_5, and to PF00004.24 AAA, and to PF02861.15 Clp_N, and to PF13191.1 AAA_16, and to PF13191.1 AAA_16; Belongs to the ClpA/ClpB family. | 0.978 |
clpP | dnaJ | CCC13826_1781 | CCC13826_0965 | ATP-dependent ClpAP/ClpXP protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | DnaK system heat shock co-chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions be [...] | 0.549 |
clpP | dnaK | CCC13826_1781 | CCC13826_2046 | ATP-dependent ClpAP/ClpXP protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | DnaK system heat shock chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.823 |
clpP | groEL | CCC13826_1781 | CCC13826_0667 | ATP-dependent ClpAP/ClpXP protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 60 kD chaperonin (cpn60); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.720 |
clpP | grpE | CCC13826_1781 | CCC13826_2045 | ATP-dependent ClpAP/ClpXP protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | DnaK system nucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Se [...] | 0.749 |
clpP | hslU | CCC13826_1781 | CCC13826_1222 | ATP-dependent ClpAP/ClpXP protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. | 0.444 |
clpP | hslV | CCC13826_1781 | CCC13826_1221 | ATP-dependent ClpAP/ClpXP protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein HslVU, ATP-dependent protease subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.670 |
clpP | htpG | CCC13826_1781 | CCC13826_1348 | ATP-dependent ClpAP/ClpXP protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein HtpG; Molecular chaperone. Has ATPase activity. | 0.482 |
clpP | lon | CCC13826_1781 | CCC13826_1958 | ATP-dependent ClpAP/ClpXP protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | DNA-binding, ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.747 |
dnaJ | clpB | CCC13826_0965 | CCC13826_0095 | DnaK system heat shock co-chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions be [...] | ATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.9 AAA_2, and to PF10431.4 ClpB_D2-small, and to PF00004.24 AAA, and to PF07728.9 AAA_5, and to PF00004.24 AAA, and to PF02861.15 Clp_N, and to PF13191.1 AAA_16, and to PF13191.1 AAA_16; Belongs to the ClpA/ClpB family. | 0.789 |