node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fhs | folD | CCV52592_0358 | CCV52592_0799 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | glyA | CCV52592_0358 | CCV52592_1350 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
fhs | infB | CCV52592_0358 | CCV52592_0355 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | 0.834 |
fhs | purC | CCV52592_0358 | CCV52592_2005 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Pfam match to PF01259.13 SAICAR_synt; Belongs to the SAICAR synthetase family. | 0.852 |
fhs | purF | CCV52592_0358 | CCV52592_0845 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.799 |
fhs | purH | CCV52592_0358 | CCV52592_1838 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | AICAR transformylase / IMP cyclohydrolase; Bifunctional; Pfam matches to PF01808.13 AICARFT_IMPCHas, and to PF02142.17 MGS. | 0.988 |
fhs | purN | CCV52592_0358 | CCV52592_1504 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.967 |
fhs | rbfA | CCV52592_0358 | CCV52592_0356 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. | 0.798 |
fhs | rimP | CCV52592_0358 | CCV52592_0357 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Putative protein (DUF150 domain); Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. | 0.797 |
fhs | thyX | CCV52592_0358 | CCV52592_2063 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.901 |
folD | fhs | CCV52592_0799 | CCV52592_0358 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.994 |
folD | glyA | CCV52592_0799 | CCV52592_1350 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.984 |
folD | purC | CCV52592_0799 | CCV52592_2005 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Pfam match to PF01259.13 SAICAR_synt; Belongs to the SAICAR synthetase family. | 0.498 |
folD | purF | CCV52592_0799 | CCV52592_0845 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.615 |
folD | purH | CCV52592_0799 | CCV52592_1838 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | AICAR transformylase / IMP cyclohydrolase; Bifunctional; Pfam matches to PF01808.13 AICARFT_IMPCHas, and to PF02142.17 MGS. | 0.976 |
folD | purN | CCV52592_0799 | CCV52592_1504 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.972 |
folD | thyX | CCV52592_0799 | CCV52592_2063 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.915 |
glyA | fhs | CCV52592_1350 | CCV52592_0358 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.965 |
glyA | folD | CCV52592_1350 | CCV52592_0799 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.984 |
glyA | purC | CCV52592_1350 | CCV52592_2005 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Pfam match to PF01259.13 SAICAR_synt; Belongs to the SAICAR synthetase family. | 0.793 |