STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bioBBiotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (279 aa)    
Predicted Functional Partners:
birA
biotin-[acetyl-CoA-carboxylase] ligase; Pfam match to PF03099.14 BPL_LplA_LipB.
  
 
 0.940
ubiE
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
  
  
 0.728
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.591
thiC
HMP-P synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
  
 0.584
gltA
Pfam match to PF00285.16 Citrate_synt; Belongs to the citrate synthase family.
     
 0.547
EAU01380.1
Na+/H+ exchanger family protein; Pfam match to PF00999.16 Na_H_Exchanger.
  
    0.507
EAU01423.1
Metallophosphatase; Pfam matches to PF12850.2 Metallophos_2, and to PF00149.23 Metallophos.
  
    0.504
cysQ
Adenosine-3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family.
       0.468
hisIE
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase; Bifunctional; Pfam matches to PF01502.13 PRA-CH, and to PF01503.12 PRA-PH; In the N-terminal section; belongs to the PRA-CH family.
     
 0.447
iscU
Iron-sulfur cluster assembly scaffold protein IscU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
    
 
 0.418
Your Current Organism:
Campylobacter curvus
NCBI taxonomy Id: 360105
Other names: C. curvus 525.92, Campylobacter curvus 525.92, Campylobacter curvus str. 525.92, Campylobacter curvus strain 525.92
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