STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
hisAN-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Pfam match to PF00977.16 His_biosynth. (236 aa)    
Predicted Functional Partners:
hisIE
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase; Bifunctional; Pfam matches to PF01502.13 PRA-CH, and to PF01503.12 PRA-PH; In the N-terminal section; belongs to the PRA-CH family.
 
 0.999
hisH
Imidazole glycerol phosphate synthase HisFH, HisH subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 0.999
hisF
Imidazole glycerol phosphate synthase HisFH, HisF subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
0.993
hisD
Histidinal dehydrogenase / histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.979
hisB
Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475.13 IGPD.
 
  
 0.978
hisG(S)
ATP phosphoribosyltransferase HisG(S)Z, hetero-octameric short form, catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.971
hisC
Histidinol-phosphate aminotransferase; Pfam match to PF00155.16 Aminotran_1_2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 0.920
pglE
UDP-4-amino-4, 6-dideoxy-alpha-D-N-acetyl-D-glucosamine transaminase; Pfam matches to PF01041.12 DegT_DnrJ_EryC1, and to PF01212.16 Beta_elim_lyase; Belongs to the DegT/DnrJ/EryC1 family.
  
    0.802
pglG
Putative membrane protein; Pfam match to PF02743.13 Cache_1.
       0.800
pglF
UDP-N-acetylglucosamine C-6 dehydratase; Pfam matches to PF02719.10 Polysacc_synt_2, and to PF01370.16 Epimerase, and to PF04321.12 RmlD_sub_bind, and to PF01073.14 3Beta_HSD, and to PF00106.20 adh_short.
       0.800
Your Current Organism:
Campylobacter curvus
NCBI taxonomy Id: 360105
Other names: C. curvus 525.92, Campylobacter curvus 525.92, Campylobacter curvus str. 525.92, Campylobacter curvus strain 525.92
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.