node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | guaB | CCV52592_1315 | CCV52592_0979 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.687 |
apt | purA | CCV52592_1315 | CCV52592_1784 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.512 |
apt | purB | CCV52592_1315 | CCV52592_1121 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Pfam matches to PF00206.15 Lyase_1, and to PF10397.4 ADSL_C; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.940 |
apt | purD | CCV52592_1315 | CCV52592_0949 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylamine-glycine ligase; Pfam matches to PF01071.14 GARS_A, and to PF02844.10 GARS_N, and to PF02843.11 GARS_C, and to PF13535.1 ATP-grasp_4, and to PF02655.9 ATP-grasp_3, and to PF02222.17 ATP-grasp, and to PF08443.6 RimK, and to PF02786.12 CPSase_L_D2; Belongs to the GARS family. | 0.459 |
apt | purF | CCV52592_1315 | CCV52592_0845 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.481 |
apt | purH | CCV52592_1315 | CCV52592_1838 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | AICAR transformylase / IMP cyclohydrolase; Bifunctional; Pfam matches to PF01808.13 AICARFT_IMPCHas, and to PF02142.17 MGS. | 0.964 |
apt | purN | CCV52592_1315 | CCV52592_1504 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.526 |
fhs | folD | CCV52592_0358 | CCV52592_0799 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | glyA | CCV52592_0358 | CCV52592_1350 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
fhs | guaB | CCV52592_0358 | CCV52592_0979 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.435 |
fhs | purD | CCV52592_0358 | CCV52592_0949 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine-glycine ligase; Pfam matches to PF01071.14 GARS_A, and to PF02844.10 GARS_N, and to PF02843.11 GARS_C, and to PF13535.1 ATP-grasp_4, and to PF02655.9 ATP-grasp_3, and to PF02222.17 ATP-grasp, and to PF08443.6 RimK, and to PF02786.12 CPSase_L_D2; Belongs to the GARS family. | 0.664 |
fhs | purF | CCV52592_0358 | CCV52592_0845 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.799 |
fhs | purH | CCV52592_0358 | CCV52592_1838 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | AICAR transformylase / IMP cyclohydrolase; Bifunctional; Pfam matches to PF01808.13 AICARFT_IMPCHas, and to PF02142.17 MGS. | 0.988 |
fhs | purN | CCV52592_0358 | CCV52592_1504 | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.967 |
folD | fhs | CCV52592_0799 | CCV52592_0358 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate--tetrahydrofolate ligase; Pfam match to PF01268.14 FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.994 |
folD | glyA | CCV52592_0799 | CCV52592_1350 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.984 |
folD | guaB | CCV52592_0799 | CCV52592_0979 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.581 |
folD | purA | CCV52592_0799 | CCV52592_1784 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.727 |
folD | purB | CCV52592_0799 | CCV52592_1121 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Pfam matches to PF00206.15 Lyase_1, and to PF10397.4 ADSL_C; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.757 |
folD | purD | CCV52592_0799 | CCV52592_0949 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylamine-glycine ligase; Pfam matches to PF01071.14 GARS_A, and to PF02844.10 GARS_N, and to PF02843.11 GARS_C, and to PF13535.1 ATP-grasp_4, and to PF02655.9 ATP-grasp_3, and to PF02222.17 ATP-grasp, and to PF08443.6 RimK, and to PF02786.12 CPSase_L_D2; Belongs to the GARS family. | 0.652 |