node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACQ69012.1 | ACQ69721.1 | EAT1b_0078 | EAT1b_0790 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: abu:Abu_0039 dCMP deaminase, putative. | PFAM: metallophosphoesterase; KEGG: bha:BH3453 hypothetical protein; Belongs to the 5'-nucleotidase family. | 0.904 |
ACQ69012.1 | ACQ69755.1 | EAT1b_0078 | EAT1b_0825 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: abu:Abu_0039 dCMP deaminase, putative. | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: bsu:BSU07840 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic precursor protein. | 0.904 |
ACQ69012.1 | ACQ69997.1 | EAT1b_0078 | EAT1b_1069 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: abu:Abu_0039 dCMP deaminase, putative. | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: bsu:BSU07840 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic precursor protein; Belongs to the 5'-nucleotidase family. | 0.904 |
ACQ69012.1 | tdk | EAT1b_0078 | EAT1b_1339 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: abu:Abu_0039 dCMP deaminase, putative. | PFAM: thymidine kinase; KEGG: bha:BH3779 thymidine kinase. | 0.930 |
ACQ69012.1 | thyA | EAT1b_0078 | EAT1b_0141 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: abu:Abu_0039 dCMP deaminase, putative. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.936 |
ACQ69012.1 | tmk | EAT1b_0078 | EAT1b_1706 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: abu:Abu_0039 dCMP deaminase, putative. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.930 |
ACQ69074.1 | gcvT | EAT1b_0140 | EAT1b_0536 | Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.913 |
ACQ69074.1 | glyA | EAT1b_0140 | EAT1b_1325 | Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
ACQ69074.1 | thyA | EAT1b_0140 | EAT1b_0141 | Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
ACQ69721.1 | ACQ69012.1 | EAT1b_0790 | EAT1b_0078 | PFAM: metallophosphoesterase; KEGG: bha:BH3453 hypothetical protein; Belongs to the 5'-nucleotidase family. | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: abu:Abu_0039 dCMP deaminase, putative. | 0.904 |
ACQ69721.1 | ACQ69755.1 | EAT1b_0790 | EAT1b_0825 | PFAM: metallophosphoesterase; KEGG: bha:BH3453 hypothetical protein; Belongs to the 5'-nucleotidase family. | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: bsu:BSU07840 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic precursor protein. | 0.946 |
ACQ69721.1 | ACQ69997.1 | EAT1b_0790 | EAT1b_1069 | PFAM: metallophosphoesterase; KEGG: bha:BH3453 hypothetical protein; Belongs to the 5'-nucleotidase family. | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: bsu:BSU07840 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic precursor protein; Belongs to the 5'-nucleotidase family. | 0.924 |
ACQ69721.1 | tdk | EAT1b_0790 | EAT1b_1339 | PFAM: metallophosphoesterase; KEGG: bha:BH3453 hypothetical protein; Belongs to the 5'-nucleotidase family. | PFAM: thymidine kinase; KEGG: bha:BH3779 thymidine kinase. | 0.902 |
ACQ69721.1 | thyA | EAT1b_0790 | EAT1b_0141 | PFAM: metallophosphoesterase; KEGG: bha:BH3453 hypothetical protein; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.911 |
ACQ69721.1 | tmk | EAT1b_0790 | EAT1b_1706 | PFAM: metallophosphoesterase; KEGG: bha:BH3453 hypothetical protein; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.908 |
ACQ69755.1 | ACQ69012.1 | EAT1b_0825 | EAT1b_0078 | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: bsu:BSU07840 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic precursor protein. | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: abu:Abu_0039 dCMP deaminase, putative. | 0.904 |
ACQ69755.1 | ACQ69721.1 | EAT1b_0825 | EAT1b_0790 | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: bsu:BSU07840 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic precursor protein. | PFAM: metallophosphoesterase; KEGG: bha:BH3453 hypothetical protein; Belongs to the 5'-nucleotidase family. | 0.946 |
ACQ69755.1 | ACQ69997.1 | EAT1b_0825 | EAT1b_1069 | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: bsu:BSU07840 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic precursor protein. | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: bsu:BSU07840 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic precursor protein; Belongs to the 5'-nucleotidase family. | 0.925 |
ACQ69755.1 | tdk | EAT1b_0825 | EAT1b_1339 | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: bsu:BSU07840 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic precursor protein. | PFAM: thymidine kinase; KEGG: bha:BH3779 thymidine kinase. | 0.902 |
ACQ69755.1 | thyA | EAT1b_0825 | EAT1b_0141 | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: bsu:BSU07840 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic precursor protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.902 |