STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prcAProteasome (alpha subunit) prca; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (267 aa)    
Predicted Functional Partners:
prcB
Proteasome (beta subunit) prcb; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation
 
 0.999
MUL_1384
Transitional endoplasmic reticulum atpase; Belongs to the AAA ATPase family
  
 0.995
pafA
Conserved hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine
   
 0.985
mpa
Proteasome-associated atpase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis
 
 0.979
pup
Prokaryotic ubiquitin-like protein pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation
 
  
 0.963
MUL_2333
Pup amidohydrolase; Conserved protein; Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein
   
 0.942
MUL_0093
Conserved protein; Cytoplasmic protein
  
 
 
 0.915
MUL_2328
Proteasome accessory factor b; Conserved protein; Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; contains domain homology to transcriptional regulators
 
  
 0.818
glpK
Glycerol kinase glpk; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
   
 0.776
MUL_3928
[cyso sulfur-carrier protein]-s-l-cysteine hydrolase; Conserved hypothetical protease; Cytoplasmic protein; function unknown but domain identity suggests this CDS encodes a metal-dependent protease of the Pad1/Jab1 superfamily
   
 0.768
Your Current Organism:
Mycobacterium ulcerans
NCBI taxonomy Id: 362242
Other names: M. ulcerans Agy99, Mycobacterium ulcerans Agy99, Mycobacterium ulcerans str. Agy99, Mycobacterium ulcerans strain Agy99
Server load: low (12%) [HD]