STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase / imp cyclohydrolase; Non-secretory protein; cytoplasmic protein; involved in de novo purine biosynthesis (at the ninth and tenth steps) [catalytic activity 1: 10- formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4- imidazolecarboxamide = tetrahydrofolate + 5'- phosphoribosyl-5-formamido-4-imidazolecarboxamide] [catalytic activity 2: imp + H2O = 5-formamido-1-(5- phosphoribosyl)imidazole-4-carboxamide] (523 aa)    
Predicted Functional Partners:
purN
5'-phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
 0.999
purB
Adenylosuccinate lyase, purb; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
  
 0.995
purA
Adenylosuccinate synthetase pura; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
 
 0.992
folD
Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate
 
 0.989
purD
Phosphoribosylamine-glycine ligase, purd; Belongs to the GARS family
 
 
 0.988
guaB2
Inosine-5'-monophosphate (imp) dehydrogenase, GuaB2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
 
 0.987
glyA1
Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
  
 0.985
glyA2
Serine hydroxymethyltransferase glya2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
  
 0.985
guaB1
Inosine-5'-monophosphate dehydrogenase GuaB1; Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in GMP biosynthesis [catalytic activity: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'- phosphate + NADH]
  
 0.984
purM
5'-phosphoribosyl-5-aminoimidazole synthetase, PurM; Phosphoribosylformylglycinamidine cyclo-ligase; Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; involved in de novo purine biosynthesis (at the fifth step) [catalytic activity: ATP + 5'- phosphoribosylformylglycinamidine = ADP + phosphate + 5'- phosphoribosyl-5-aminoimidazole]
 
 
 0.983
Your Current Organism:
Mycobacterium ulcerans
NCBI taxonomy Id: 362242
Other names: M. ulcerans Agy99, Mycobacterium ulcerans Agy99, Mycobacterium ulcerans str. Agy99, Mycobacterium ulcerans strain Agy99
Server load: low (14%) [HD]