Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| folD | glyA1 | MUL_1428 | MUL_0188 | Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate | Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.981 |
| folD | glyA2 | MUL_1428 | MUL_4902 | Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate | Serine hydroxymethyltransferase glya2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.981 |
| folD | guaB1 | MUL_1428 | MUL_3036 | Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate | Inosine-5'-monophosphate dehydrogenase GuaB1; Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in GMP biosynthesis [catalytic activity: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'- phosphate + NADH] | 0.777 |
| folD | guaB2 | MUL_1428 | MUL_0900 | Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate | Inosine-5'-monophosphate (imp) dehydrogenase, GuaB2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.777 |
| folD | purA | MUL_1428 | MUL_2834 | Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate | Adenylosuccinate synthetase pura; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.536 |
| folD | purB | MUL_1428 | MUL_0490 | Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate | Adenylosuccinate lyase, purb; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | 0.871 |
| folD | purD | MUL_1428 | MUL_0481 | Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate | Phosphoribosylamine-glycine ligase, purd; Belongs to the GARS family | 0.809 |
| folD | purH | MUL_1428 | MUL_4712 | Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate | Phosphoribosylaminoimidazolecarboxamide formyltransferase / imp cyclohydrolase; Non-secretory protein; cytoplasmic protein; involved in de novo purine biosynthesis (at the ninth and tenth steps) [catalytic activity 1: 10- formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4- imidazolecarboxamide = tetrahydrofolate + 5'- phosphoribosyl-5-formamido-4-imidazolecarboxamide] [catalytic activity 2: imp + H2O = 5-formamido-1-(5- phosphoribosyl)imidazole-4-carboxamide] | 0.989 |
| folD | purN | MUL_1428 | MUL_4713 | Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate | 5'-phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate | 0.974 |
| glyA1 | folD | MUL_0188 | MUL_1428 | Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate | 0.981 |
| glyA1 | glyA2 | MUL_0188 | MUL_4902 | Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Serine hydroxymethyltransferase glya2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.804 |
| glyA1 | guaB1 | MUL_0188 | MUL_3036 | Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Inosine-5'-monophosphate dehydrogenase GuaB1; Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in GMP biosynthesis [catalytic activity: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'- phosphate + NADH] | 0.535 |
| glyA1 | guaB2 | MUL_0188 | MUL_0900 | Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Inosine-5'-monophosphate (imp) dehydrogenase, GuaB2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.535 |
| glyA1 | purA | MUL_0188 | MUL_2834 | Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Adenylosuccinate synthetase pura; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.472 |
| glyA1 | purB | MUL_0188 | MUL_0490 | Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Adenylosuccinate lyase, purb; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | 0.658 |
| glyA1 | purD | MUL_0188 | MUL_0481 | Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Phosphoribosylamine-glycine ligase, purd; Belongs to the GARS family | 0.816 |
| glyA1 | purH | MUL_0188 | MUL_4712 | Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Phosphoribosylaminoimidazolecarboxamide formyltransferase / imp cyclohydrolase; Non-secretory protein; cytoplasmic protein; involved in de novo purine biosynthesis (at the ninth and tenth steps) [catalytic activity 1: 10- formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4- imidazolecarboxamide = tetrahydrofolate + 5'- phosphoribosyl-5-formamido-4-imidazolecarboxamide] [catalytic activity 2: imp + H2O = 5-formamido-1-(5- phosphoribosyl)imidazole-4-carboxamide] | 0.985 |
| glyA1 | purN | MUL_0188 | MUL_4713 | Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 5'-phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate | 0.962 |
| glyA2 | folD | MUL_4902 | MUL_1428 | Serine hydroxymethyltransferase glya2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Bifunctional protein: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase, fold; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate | 0.981 |
| glyA2 | glyA1 | MUL_4902 | MUL_0188 | Serine hydroxymethyltransferase glya2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Serine hydroxymethyltransferase 1 glya1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.804 |
page 1 of 6
