node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HQ_1756A | HQ_1856A | HQ_1756A | HQ_1856A | Homolog to 5,10-methylenetetrahydrofolate reductase. | Homolog to glycine cleavage system protein T. | 0.967 |
HQ_1756A | HQ_3112A | HQ_1756A | HQ_3112A | Homolog to 5,10-methylenetetrahydrofolate reductase. | Homolog to glycine cleavage system protein T. | 0.937 |
HQ_1756A | fhs | HQ_1756A | HQ_1768A | Homolog to 5,10-methylenetetrahydrofolate reductase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.462 |
HQ_1756A | folD | HQ_1756A | HQ_2790A | Homolog to 5,10-methylenetetrahydrofolate reductase. | Methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.934 |
HQ_1756A | glyA | HQ_1756A | HQ_2791A | Homolog to 5,10-methylenetetrahydrofolate reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |
HQ_1756A | hts | HQ_1756A | HQ_2456A | Homolog to 5,10-methylenetetrahydrofolate reductase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.951 |
HQ_1756A | purNH | HQ_1756A | HQ_1661A | Homolog to 5,10-methylenetetrahydrofolate reductase. | Phosphoribosylglycinamide formyltransferase / phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.502 |
HQ_1756A | purU | HQ_1756A | HQ_3129A | Homolog to 5,10-methylenetetrahydrofolate reductase. | Formyltetrahydrofolate deformylase. | 0.430 |
HQ_1856A | HQ_1756A | HQ_1856A | HQ_1756A | Homolog to glycine cleavage system protein T. | Homolog to 5,10-methylenetetrahydrofolate reductase. | 0.967 |
HQ_1856A | HQ_3112A | HQ_1856A | HQ_3112A | Homolog to glycine cleavage system protein T. | Homolog to glycine cleavage system protein T. | 0.963 |
HQ_1856A | fhs | HQ_1856A | HQ_1768A | Homolog to glycine cleavage system protein T. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.936 |
HQ_1856A | folD | HQ_1856A | HQ_2790A | Homolog to glycine cleavage system protein T. | Methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.924 |
HQ_1856A | glyA | HQ_1856A | HQ_2791A | Homolog to glycine cleavage system protein T. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |
HQ_1856A | hts | HQ_1856A | HQ_2456A | Homolog to glycine cleavage system protein T. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.913 |
HQ_1856A | purNH | HQ_1856A | HQ_1661A | Homolog to glycine cleavage system protein T. | Phosphoribosylglycinamide formyltransferase / phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.929 |
HQ_1856A | purT | HQ_1856A | HQ_1464A | Homolog to glycine cleavage system protein T. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.908 |
HQ_1856A | purU | HQ_1856A | HQ_3129A | Homolog to glycine cleavage system protein T. | Formyltetrahydrofolate deformylase. | 0.914 |
HQ_3112A | HQ_1756A | HQ_3112A | HQ_1756A | Homolog to glycine cleavage system protein T. | Homolog to 5,10-methylenetetrahydrofolate reductase. | 0.937 |
HQ_3112A | HQ_1856A | HQ_3112A | HQ_1856A | Homolog to glycine cleavage system protein T. | Homolog to glycine cleavage system protein T. | 0.963 |
HQ_3112A | fhs | HQ_3112A | HQ_1768A | Homolog to glycine cleavage system protein T. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.924 |