STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiEThiamine monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (217 aa)    
Predicted Functional Partners:
thiD
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
 0.999
thiG
Uncharacterized enzyme of thiazole biosynthesis; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.977
thiC
Thiamine biosynthesis protein ThiC.
 
  
 0.965
thiL
Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
    
 0.942
thiH
Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.
  
  
 0.895
thiF
Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family.
     0.854
hemL
Glutamate-1-semialdehyde aminotransferase.
    
 0.662
ftsY
Signal renition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
       0.619
ribA
GTP cyclohydrolase II; In the N-terminal section; belongs to the DHBP synthase family.
     
 0.539
iscU
NifU homolog involved in Fe-S cluster formation.
     
 0.495
Your Current Organism:
Lawsonia intracellularis
NCBI taxonomy Id: 363253
Other names: L. intracellularis PHE/MN1-00, Lawsonia intracellularis PHE/MN1-00, Lawsonia intracellularis str. PHE/MN1-00, Lawsonia intracellularis strain PHE/MN1-00
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