STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hyaBHydrogenase-1 large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (602 aa)    
Predicted Functional Partners:
hyaA
Hydrogenase-1 small subunit.
 0.999
hyaC
Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit.
 
 
 0.997
porA
Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit.
  
  
 0.994
hyaD
Processing of HyaA and HyaB proteins.
 
 
 0.957
hypA
Zn finger protein HypA/HybF (possibly regulating hydrogenase expression); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
  
 
 0.874
hypD
Hydrogenase maturation factor; Belongs to the HypD family.
  
 
 0.586
LI1084
Fe-S oxidoreductase.
  
 
 0.493
hypF
Hydrogenase maturation factor; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
   
 
 0.480
iscU
NifU homolog involved in Fe-S cluster formation.
     
 0.462
hypB
Hydrogenase accessory protein HypB.
  
  
 0.449
Your Current Organism:
Lawsonia intracellularis
NCBI taxonomy Id: 363253
Other names: L. intracellularis PHE/MN1-00, Lawsonia intracellularis PHE/MN1-00, Lawsonia intracellularis str. PHE/MN1-00, Lawsonia intracellularis strain PHE/MN1-00
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.