node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
adk | guaA | LI0317 | LI0590 | Adenylate kinase and related kinases; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | 0.563 |
adk | guaB | LI0317 | LI0591 | Adenylate kinase and related kinases; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.440 |
adk | purB | LI0317 | LI0997 | Adenylate kinase and related kinases; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.950 |
adk | pyrH | LI0317 | LI0382 | Adenylate kinase and related kinases; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.549 |
adk | surE | LI0317 | LI0762 | Adenylate kinase and related kinases; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Predicted acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
adk | tmk | LI0317 | LI0760 | Adenylate kinase and related kinases; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.420 |
cmk | guaA | LI0910 | LI0590 | Cytidylate kinase. | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | 0.544 |
cmk | guaB | LI0910 | LI0591 | Cytidylate kinase. | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.537 |
cmk | pyrF | LI0910 | LI0311 | Cytidylate kinase. | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.437 |
cmk | surE | LI0910 | LI0762 | Cytidylate kinase. | Predicted acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.923 |
guaA | adk | LI0590 | LI0317 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Adenylate kinase and related kinases; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.563 |
guaA | cmk | LI0590 | LI0910 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Cytidylate kinase. | 0.544 |
guaA | guaB | LI0590 | LI0591 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | purA | LI0590 | LI0202 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.785 |
guaA | purB | LI0590 | LI0997 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.819 |
guaA | pyrF | LI0590 | LI0311 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.589 |
guaA | pyrH | LI0590 | LI0382 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.712 |
guaA | surE | LI0590 | LI0762 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Predicted acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.956 |
guaA | tmk | LI0590 | LI0760 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.463 |
guaA | upp | LI0590 | LI0015 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase. | 0.507 |