node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pnap_0907 | hrcA | Pnap_0907 | Pnap_0909 | DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.761 |
Pnap_0907 | nadK | Pnap_0907 | Pnap_0908 | DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.946 |
Pnap_0961 | clpB | Pnap_0961 | Pnap_2225 | ATP-dependent Clp protease proteolytic subunit ClpP; PFAM: peptidase S14, ClpP; KEGG: sdn:Sden_3249 peptidase S14, ClpP; Belongs to the peptidase S14 family. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.736 |
Pnap_0961 | dnaK | Pnap_0961 | Pnap_1526 | ATP-dependent Clp protease proteolytic subunit ClpP; PFAM: peptidase S14, ClpP; KEGG: sdn:Sden_3249 peptidase S14, ClpP; Belongs to the peptidase S14 family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.432 |
Pnap_0961 | grpE | Pnap_0961 | Pnap_1527 | ATP-dependent Clp protease proteolytic subunit ClpP; PFAM: peptidase S14, ClpP; KEGG: sdn:Sden_3249 peptidase S14, ClpP; Belongs to the peptidase S14 family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.531 |
Pnap_0961 | hrcA | Pnap_0961 | Pnap_0909 | ATP-dependent Clp protease proteolytic subunit ClpP; PFAM: peptidase S14, ClpP; KEGG: sdn:Sden_3249 peptidase S14, ClpP; Belongs to the peptidase S14 family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.660 |
Pnap_1795 | clpB | Pnap_1795 | Pnap_2225 | KEGG: pol:Bpro_2651 putative heat shock protein. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.685 |
Pnap_1795 | dnaJ | Pnap_1795 | Pnap_1525 | KEGG: pol:Bpro_2651 putative heat shock protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.767 |
Pnap_1795 | grpE | Pnap_1795 | Pnap_1527 | KEGG: pol:Bpro_2651 putative heat shock protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.837 |
Pnap_1795 | hrcA | Pnap_1795 | Pnap_0909 | KEGG: pol:Bpro_2651 putative heat shock protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.646 |
Pnap_2253 | clpB | Pnap_2253 | Pnap_2225 | PFAM: peptidase S14, ClpP; KEGG: stm:STM0912 ATP-dependent protease; Belongs to the peptidase S14 family. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.693 |
Pnap_2253 | dnaK | Pnap_2253 | Pnap_1526 | PFAM: peptidase S14, ClpP; KEGG: stm:STM0912 ATP-dependent protease; Belongs to the peptidase S14 family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.432 |
Pnap_2253 | grpE | Pnap_2253 | Pnap_1527 | PFAM: peptidase S14, ClpP; KEGG: stm:STM0912 ATP-dependent protease; Belongs to the peptidase S14 family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.531 |
Pnap_2253 | hrcA | Pnap_2253 | Pnap_0909 | PFAM: peptidase S14, ClpP; KEGG: stm:STM0912 ATP-dependent protease; Belongs to the peptidase S14 family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.660 |
clpB | Pnap_0961 | Pnap_2225 | Pnap_0961 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit ClpP; PFAM: peptidase S14, ClpP; KEGG: sdn:Sden_3249 peptidase S14, ClpP; Belongs to the peptidase S14 family. | 0.736 |
clpB | Pnap_1795 | Pnap_2225 | Pnap_1795 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | KEGG: pol:Bpro_2651 putative heat shock protein. | 0.685 |
clpB | Pnap_2253 | Pnap_2225 | Pnap_2253 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | PFAM: peptidase S14, ClpP; KEGG: stm:STM0912 ATP-dependent protease; Belongs to the peptidase S14 family. | 0.693 |
clpB | clpP | Pnap_2225 | Pnap_2957 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.780 |
clpB | dnaJ | Pnap_2225 | Pnap_1525 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.698 |
clpB | dnaK | Pnap_2225 | Pnap_1526 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.754 |