node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pnap_1783 | Pnap_3253 | Pnap_1783 | Pnap_3253 | PFAM: 20S proteasome, A and B subunits; KEGG: pol:Bpro_2670 20S proteasome, A and B subunits. | PFAM: heat shock protein DnaJ domain protein; KEGG: pol:Bpro_3897 heat shock protein DnaJ-like. | 0.425 |
Pnap_1783 | clpB | Pnap_1783 | Pnap_2225 | PFAM: 20S proteasome, A and B subunits; KEGG: pol:Bpro_2670 20S proteasome, A and B subunits. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.461 |
Pnap_1783 | dnaJ | Pnap_1783 | Pnap_1525 | PFAM: 20S proteasome, A and B subunits; KEGG: pol:Bpro_2670 20S proteasome, A and B subunits. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.425 |
Pnap_1783 | groL1 | Pnap_1783 | Pnap_0389 | PFAM: 20S proteasome, A and B subunits; KEGG: pol:Bpro_2670 20S proteasome, A and B subunits. | Thermosome subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.661 |
Pnap_1783 | groL2 | Pnap_1783 | Pnap_0657 | PFAM: 20S proteasome, A and B subunits; KEGG: pol:Bpro_2670 20S proteasome, A and B subunits. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.661 |
Pnap_1783 | groS | Pnap_1783 | Pnap_0658 | PFAM: 20S proteasome, A and B subunits; KEGG: pol:Bpro_2670 20S proteasome, A and B subunits. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.818 |
Pnap_1783 | grpE | Pnap_1783 | Pnap_1527 | PFAM: 20S proteasome, A and B subunits; KEGG: pol:Bpro_2670 20S proteasome, A and B subunits. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.871 |
Pnap_3253 | Pnap_1783 | Pnap_3253 | Pnap_1783 | PFAM: heat shock protein DnaJ domain protein; KEGG: pol:Bpro_3897 heat shock protein DnaJ-like. | PFAM: 20S proteasome, A and B subunits; KEGG: pol:Bpro_2670 20S proteasome, A and B subunits. | 0.425 |
Pnap_3253 | clpB | Pnap_3253 | Pnap_2225 | PFAM: heat shock protein DnaJ domain protein; KEGG: pol:Bpro_3897 heat shock protein DnaJ-like. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.583 |
Pnap_3253 | dnaK | Pnap_3253 | Pnap_1526 | PFAM: heat shock protein DnaJ domain protein; KEGG: pol:Bpro_3897 heat shock protein DnaJ-like. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.911 |
Pnap_3253 | groL1 | Pnap_3253 | Pnap_0389 | PFAM: heat shock protein DnaJ domain protein; KEGG: pol:Bpro_3897 heat shock protein DnaJ-like. | Thermosome subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.733 |
Pnap_3253 | groL2 | Pnap_3253 | Pnap_0657 | PFAM: heat shock protein DnaJ domain protein; KEGG: pol:Bpro_3897 heat shock protein DnaJ-like. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.722 |
Pnap_3253 | groS | Pnap_3253 | Pnap_0658 | PFAM: heat shock protein DnaJ domain protein; KEGG: pol:Bpro_3897 heat shock protein DnaJ-like. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.529 |
Pnap_3253 | grpE | Pnap_3253 | Pnap_1527 | PFAM: heat shock protein DnaJ domain protein; KEGG: pol:Bpro_3897 heat shock protein DnaJ-like. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.875 |
Pnap_3253 | hrcA | Pnap_3253 | Pnap_0909 | PFAM: heat shock protein DnaJ domain protein; KEGG: pol:Bpro_3897 heat shock protein DnaJ-like. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.559 |
Pnap_3253 | hscA-2 | Pnap_3253 | Pnap_2286 | PFAM: heat shock protein DnaJ domain protein; KEGG: pol:Bpro_3897 heat shock protein DnaJ-like. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.902 |
clpB | Pnap_1783 | Pnap_2225 | Pnap_1783 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | PFAM: 20S proteasome, A and B subunits; KEGG: pol:Bpro_2670 20S proteasome, A and B subunits. | 0.461 |
clpB | Pnap_3253 | Pnap_2225 | Pnap_3253 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein DnaJ domain protein; KEGG: pol:Bpro_3897 heat shock protein DnaJ-like. | 0.583 |
clpB | dnaJ | Pnap_2225 | Pnap_1525 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.698 |
clpB | dnaK | Pnap_2225 | Pnap_1526 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.754 |