node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pnap_3449 | htpX | Pnap_3449 | Pnap_3448 | KEGG: pol:Bpro_1031 putative transmembrane protein. | Heat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | 0.603 |
Pnap_3449 | pyrC | Pnap_3449 | Pnap_3451 | KEGG: pol:Bpro_1031 putative transmembrane protein. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.711 |
Pnap_3864 | grpE | Pnap_3864 | Pnap_1527 | PFAM: Thioredoxin domain; KEGG: pol:Bpro_4628 thioredoxin. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.831 |
Pnap_3864 | htpX | Pnap_3864 | Pnap_3448 | PFAM: Thioredoxin domain; KEGG: pol:Bpro_4628 thioredoxin. | Heat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | 0.404 |
grpE | Pnap_3864 | Pnap_1527 | Pnap_3864 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | PFAM: Thioredoxin domain; KEGG: pol:Bpro_4628 thioredoxin. | 0.831 |
grpE | htpX | Pnap_1527 | Pnap_3448 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | Heat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | 0.463 |
htpX | Pnap_3449 | Pnap_3448 | Pnap_3449 | Heat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | KEGG: pol:Bpro_1031 putative transmembrane protein. | 0.603 |
htpX | Pnap_3864 | Pnap_3448 | Pnap_3864 | Heat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | PFAM: Thioredoxin domain; KEGG: pol:Bpro_4628 thioredoxin. | 0.404 |
htpX | grpE | Pnap_3448 | Pnap_1527 | Heat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.463 |
htpX | pyrC | Pnap_3448 | Pnap_3451 | Heat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.559 |
pyrC | Pnap_3449 | Pnap_3451 | Pnap_3449 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | KEGG: pol:Bpro_1031 putative transmembrane protein. | 0.711 |
pyrC | htpX | Pnap_3451 | Pnap_3448 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | Heat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | 0.559 |