node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Smed_0511 | Smed_0648 | Smed_0511 | Smed_0648 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: sme:SMc00003 putative chaperone protein. | KEGG: sme:SMc02376 putative heat shock protein. | 0.904 |
Smed_0511 | clpB | Smed_0511 | Smed_2499 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: sme:SMc00003 putative chaperone protein. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.687 |
Smed_0511 | dnaK | Smed_0511 | Smed_3389 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: sme:SMc00003 putative chaperone protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.968 |
Smed_0511 | groL1 | Smed_0511 | Smed_0408 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: sme:SMc00003 putative chaperone protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.676 |
Smed_0511 | groL3 | Smed_0511 | Smed_1281 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: sme:SMc00003 putative chaperone protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.678 |
Smed_0511 | grpE | Smed_0511 | Smed_0012 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: sme:SMc00003 putative chaperone protein. | Ribulose-phosphate 3-epimerase; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.887 |
Smed_0511 | hrcA | Smed_0511 | Smed_0011 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: sme:SMc00003 putative chaperone protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.696 |
Smed_0511 | hslU | Smed_0511 | Smed_3266 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: sme:SMc00003 putative chaperone protein. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.624 |
Smed_0511 | hslV | Smed_0511 | Smed_3264 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: sme:SMc00003 putative chaperone protein. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.481 |
Smed_0648 | Smed_0511 | Smed_0648 | Smed_0511 | KEGG: sme:SMc02376 putative heat shock protein. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: sme:SMc00003 putative chaperone protein. | 0.904 |
Smed_0648 | clpB | Smed_0648 | Smed_2499 | KEGG: sme:SMc02376 putative heat shock protein. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.907 |
Smed_0648 | dnaJ | Smed_0648 | Smed_3390 | KEGG: sme:SMc02376 putative heat shock protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.909 |
Smed_0648 | groL1 | Smed_0648 | Smed_0408 | KEGG: sme:SMc02376 putative heat shock protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.763 |
Smed_0648 | groL3 | Smed_0648 | Smed_1281 | KEGG: sme:SMc02376 putative heat shock protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.763 |
Smed_0648 | grpE | Smed_0648 | Smed_0012 | KEGG: sme:SMc02376 putative heat shock protein. | Ribulose-phosphate 3-epimerase; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.952 |
Smed_0648 | hrcA | Smed_0648 | Smed_0011 | KEGG: sme:SMc02376 putative heat shock protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.815 |
Smed_0648 | hslU | Smed_0648 | Smed_3266 | KEGG: sme:SMc02376 putative heat shock protein. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.590 |
Smed_0648 | hslV | Smed_0648 | Smed_3264 | KEGG: sme:SMc02376 putative heat shock protein. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.513 |
clpB | Smed_0511 | Smed_2499 | Smed_0511 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: sme:SMc00003 putative chaperone protein. | 0.687 |
clpB | Smed_0648 | Smed_2499 | Smed_0648 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | KEGG: sme:SMc02376 putative heat shock protein. | 0.907 |