node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CobU | Smed_1562 | Smed_1761 | Smed_1562 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. | 0.811 |
CobU | Smed_1744 | Smed_1761 | Smed_1744 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | PFAM: aminotransferase class I and II; KEGG: sme:SMc04281 probable cobalamin biosynthesis protein pyridoxal-phosphate-dependent aminotransferase. | 0.979 |
CobU | Smed_1747 | Smed_1761 | Smed_1747 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | KEGG: sme:SMc04285 probable cobalamin biosynthesis protein. | 0.423 |
CobU | Smed_1758 | Smed_1761 | Smed_1758 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.993 |
CobU | Smed_2812 | Smed_1761 | Smed_2812 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sme:SMc03187 probable precorrin-4 C11-methyltransferase protein; Belongs to the precorrin methyltransferase family. | 0.861 |
CobU | cobB | Smed_1761 | Smed_1745 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.906 |
CobU | cobD | Smed_1761 | Smed_1743 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.992 |
CobU | cobQ | Smed_1761 | Smed_1765 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.938 |
CobU | cobS | Smed_1761 | Smed_1604 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.988 |
CobU | cobT | Smed_1761 | Smed_1603 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.986 |
Smed_1562 | CobU | Smed_1562 | Smed_1761 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.811 |
Smed_1562 | Smed_1744 | Smed_1562 | Smed_1744 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. | PFAM: aminotransferase class I and II; KEGG: sme:SMc04281 probable cobalamin biosynthesis protein pyridoxal-phosphate-dependent aminotransferase. | 0.628 |
Smed_1562 | Smed_1758 | Smed_1562 | Smed_1758 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.452 |
Smed_1562 | Smed_2812 | Smed_1562 | Smed_2812 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. | TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sme:SMc03187 probable precorrin-4 C11-methyltransferase protein; Belongs to the precorrin methyltransferase family. | 0.429 |
Smed_1562 | cobB | Smed_1562 | Smed_1745 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.825 |
Smed_1562 | cobD | Smed_1562 | Smed_1743 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.463 |
Smed_1562 | cobQ | Smed_1562 | Smed_1765 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.468 |
Smed_1562 | cobS | Smed_1562 | Smed_1604 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.444 |
Smed_1562 | cobT | Smed_1562 | Smed_1603 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.989 |
Smed_1744 | CobU | Smed_1744 | Smed_1761 | PFAM: aminotransferase class I and II; KEGG: sme:SMc04281 probable cobalamin biosynthesis protein pyridoxal-phosphate-dependent aminotransferase. | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.979 |