node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Smed_1037 | Smed_1450 | Smed_1037 | Smed_1450 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: sme:SMc01256 probable L-serine dehydratase protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc00290 probable lactoylglutathione lyase methylglyoxalase protein. | 0.801 |
Smed_1037 | Smed_2446 | Smed_1037 | Smed_2446 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: sme:SMc01256 probable L-serine dehydratase protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. | PFAM: aldehyde dehydrogenase; KEGG: mpt:Mpe_A0361 lactaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.824 |
Smed_1037 | Smed_3362 | Smed_1037 | Smed_3362 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: sme:SMc01256 probable L-serine dehydratase protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc02828 putative hydroxyacid dehydrogenase protein. | 0.801 |
Smed_1037 | dsdA | Smed_1037 | Smed_2092 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: sme:SMc01256 probable L-serine dehydratase protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. | TIGRFAM: D-serine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ajs:Ajs_2250 D-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. | 0.915 |
Smed_1037 | ilvA | Smed_1037 | Smed_1373 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: sme:SMc01256 probable L-serine dehydratase protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.937 |
Smed_1450 | Smed_1037 | Smed_1450 | Smed_1037 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc00290 probable lactoylglutathione lyase methylglyoxalase protein. | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: sme:SMc01256 probable L-serine dehydratase protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.801 |
Smed_1450 | Smed_2446 | Smed_1450 | Smed_2446 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc00290 probable lactoylglutathione lyase methylglyoxalase protein. | PFAM: aldehyde dehydrogenase; KEGG: mpt:Mpe_A0361 lactaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.902 |
Smed_1450 | Smed_3362 | Smed_1450 | Smed_3362 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc00290 probable lactoylglutathione lyase methylglyoxalase protein. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc02828 putative hydroxyacid dehydrogenase protein. | 0.900 |
Smed_1450 | dsdA | Smed_1450 | Smed_2092 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc00290 probable lactoylglutathione lyase methylglyoxalase protein. | TIGRFAM: D-serine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ajs:Ajs_2250 D-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. | 0.800 |
Smed_1450 | ilvA | Smed_1450 | Smed_1373 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc00290 probable lactoylglutathione lyase methylglyoxalase protein. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.825 |
Smed_2446 | Smed_1037 | Smed_2446 | Smed_1037 | PFAM: aldehyde dehydrogenase; KEGG: mpt:Mpe_A0361 lactaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: sme:SMc01256 probable L-serine dehydratase protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.824 |
Smed_2446 | Smed_1450 | Smed_2446 | Smed_1450 | PFAM: aldehyde dehydrogenase; KEGG: mpt:Mpe_A0361 lactaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc00290 probable lactoylglutathione lyase methylglyoxalase protein. | 0.902 |
Smed_2446 | Smed_3362 | Smed_2446 | Smed_3362 | PFAM: aldehyde dehydrogenase; KEGG: mpt:Mpe_A0361 lactaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc02828 putative hydroxyacid dehydrogenase protein. | 0.912 |
Smed_2446 | dsdA | Smed_2446 | Smed_2092 | PFAM: aldehyde dehydrogenase; KEGG: mpt:Mpe_A0361 lactaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | TIGRFAM: D-serine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ajs:Ajs_2250 D-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. | 0.800 |
Smed_2446 | ilvA | Smed_2446 | Smed_1373 | PFAM: aldehyde dehydrogenase; KEGG: mpt:Mpe_A0361 lactaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.815 |
Smed_3362 | Smed_1037 | Smed_3362 | Smed_1037 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc02828 putative hydroxyacid dehydrogenase protein. | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: sme:SMc01256 probable L-serine dehydratase protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.801 |
Smed_3362 | Smed_1450 | Smed_3362 | Smed_1450 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc02828 putative hydroxyacid dehydrogenase protein. | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc00290 probable lactoylglutathione lyase methylglyoxalase protein. | 0.900 |
Smed_3362 | Smed_2446 | Smed_3362 | Smed_2446 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc02828 putative hydroxyacid dehydrogenase protein. | PFAM: aldehyde dehydrogenase; KEGG: mpt:Mpe_A0361 lactaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.912 |
Smed_3362 | dsdA | Smed_3362 | Smed_2092 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc02828 putative hydroxyacid dehydrogenase protein. | TIGRFAM: D-serine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ajs:Ajs_2250 D-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. | 0.823 |
Smed_3362 | ilvA | Smed_3362 | Smed_1373 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc02828 putative hydroxyacid dehydrogenase protein. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.847 |